Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells.

Cell Reports
Yiyuan LiuEffie Apostolou

Abstract

During mitosis, transcription is halted and many chromatin features are lost, posing a challenge for the continuity of cell identity, particularly in fast cycling stem cells, which constantly balance self-renewal with differentiation. Here we show that, in pluripotent stem cells, certain histone marks and stem cell regulators remain associated with specific genomic regions of mitotic chromatin, a phenomenon known as mitotic bookmarking. Enhancers of stem cell-related genes are bookmarked by both H3K27ac and the master regulators OCT4, SOX2, and KLF4, while promoters of housekeeping genes retain high levels of mitotic H3K27ac in a cell-type invariant manner. Temporal degradation of OCT4 during mitotic exit compromises its ability both to maintain and induce pluripotency, suggesting that its regulatory function partly depends on its bookmarking activity. Together, our data document a widespread yet specific bookmarking by histone modifications and transcription factors promoting faithful and efficient propagation of stemness after cell division.

Citations

Jun 3, 2017·Cell Stem Cell·Xin Huang, Jianlong Wang
Jun 28, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Makiko Iwafuchi-Doi
Oct 19, 2017·Development·Nicola FestucciaPablo Navarro
Jan 19, 2019·Genome Research·Nicola FestucciaPablo Navarro
Sep 16, 2017·Science·Katherine C PalozolaKenneth S Zaret
May 28, 2019·Genes & Development·Leighton Core, Karen Adelman
Sep 5, 2018·Molecular Systems Biology·Samuel C WolffJeremy E Purvis
Sep 27, 2019·Molecular Systems Biology·Daniel StrebingerDavid M Suter
Sep 25, 2019·Nature Cell Biology·Dafne Campigli Di GiammartinoEffie Apostolou
Aug 26, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne K Voss, Tim Thomas
Feb 1, 2019·Nature Communications·Mahé RaccaudDavid M Suter
Mar 7, 2019·International Journal of Molecular Sciences·Shunya GotoYasufumi Murakami
Jan 1, 2020·Journal of Translational Medicine·Sandra Laner-PlambergerKatharina Schallmoser
Nov 14, 2018·Nature Reviews. Molecular Cell Biology·Katherine C PalozolaKenneth S Zaret
Jul 6, 2018·Frontiers in Cell and Developmental Biology·Lamuk Zaveri, Jyotsna Dhawan
Sep 29, 2019·FEBS Letters·Xiao HuShangqin Guo
Aug 28, 2020·Frontiers in Cell and Developmental Biology·William A Scott, Eric I Campos
Sep 23, 2020·Nature Reviews. Genetics·Bercin K Cenik, Ali Shilatifard
Jul 14, 2018·Molecular Cancer Research : MCR·Sayyed K ZaidiGary S Stein
Jan 15, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Sudhir KumarRakesh K Tyagi
Jan 18, 2021·Current Opinion in Cell Biology·Inma GonzalezPablo Navarro
Feb 10, 2021·Nature Genetics·Mario IurlaroDirk Schübeler
Feb 4, 2021·Current Opinion in Cell Biology·Adel Elsherbiny, Gergana Dobreva
Oct 29, 2020·Genome Génome / Conseil National De Recherches Canada·Rachel M PriceSheila S Teves
Sep 10, 2018·The Journal of Allergy and Clinical Immunology·Christian SchmidlMarkus Feuerer
May 18, 2020·Seminars in Cell & Developmental Biology·Siwanon JirawatnotaiMethichit Wattanapanitch
Aug 28, 2021·Cells·Evangelia C TachmatzidiIannis Talianidis

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