Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing

Molecular Cell
Li LiVictor G Corces


Chromosomes of metazoan organisms are partitioned in the interphase nucleus into discrete topologically associating domains (TADs). Borders between TADs are formed in regions containing active genes and clusters of architectural protein binding sites. The transcription of most genes is repressed after temperature stress in Drosophila. Here we show that temperature stress induces relocalization of architectural proteins from TAD borders to inside TADs, and this is accompanied by a dramatic rearrangement in the 3D organization of the nucleus. TAD border strength declines, allowing for an increase in long-distance inter-TAD interactions. Similar but quantitatively weaker effects are observed upon inhibition of transcription or depletion of individual architectural proteins. Heat shock-induced inter-TAD interactions result in increased contacts among enhancers and promoters of silenced genes, which recruit Pc and form Pc bodies in the nucleolus. These results suggest that the TAD organization of metazoan genomes is plastic and can be reconfigured quickly.


Dec 19, 2006·Nature Reviews. Genetics·Yuri B Schwartz, Vincenzo Pirrotta
Aug 19, 2008·Genes & Development·Claudio D'AmbrosioFrank Uhlmann
Sep 19, 2008·Genome Biology·Yong ZhangX Shirley Liu
Nov 29, 2008·Science·Tom A HartlGiovanni Bosco
Jun 10, 2010·PLoS Genetics·Caline S KaramVictor G Corces
Dec 20, 2011·Current Opinion in Genetics & Development·Vincenzo Pirrotta, Hua-Bing Li
Feb 18, 2012·Current Opinion in Cell Biology·Anna DelestGiacomo Cavalli
Apr 6, 2012·PLoS Genetics·Michael J GuertinJohn T Lis
Dec 29, 2012·Journal of Visualized Experiments : JoVE·Haipeng XingMichael Q Zhang
May 25, 2013·Genome Research·Laura E DeMareJames P Noonan
May 28, 2013·Cell·Jennifer E Phillips-CreminsVictor G Corces
Jul 9, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Elphège P NoraEdith Heard
Nov 5, 2013·The EMBO Journal·Sevil SofuevaSuzana Hadjur
Jan 18, 2014·Current Opinion in Genetics & Development·Thierry Cheutin, Giacomo Cavalli
Jul 8, 2014·Current Opinion in Genetics & Development·Giancarlo BonoraMatthew Denholtz
May 6, 2015·Annual Review of Genomics and Human Genetics·Knut ReinertDirk J Evers

❮ Previous
Next ❯


Feb 9, 2016·Current Opinion in Genetics & Development·M Ryan Corces, Victor G Corces
Feb 8, 2016·Current Opinion in Cell Biology·M Jordan Rowley, Victor G Corces
May 27, 2015·FEBS Letters·Caelin Cubeñas-Potts, Victor G Corces
Sep 9, 2015·FEBS Letters·Job Dekker, Edith Heard
Sep 30, 2015·Nucleus·Caelin Cubeñas-Potts, Victor G Corces
Jan 14, 2016·Nature Communications·Ajazul H WaniNicole J Francis
Dec 18, 2015·Trends in Biochemical Sciences·Takashi KondoHaruhiko Koseki
Dec 15, 2015·Seminars in Cell & Developmental Biology·Chenhuan Xu, Victor G Corces
Mar 8, 2016·Nature Reviews. Genetics·Wenbo LiMichael G Rosenfeld
Oct 6, 2015·Annual Review of Genetics·Huy Q Nguyen, Giovanni Bosco
Mar 11, 2016·Nucleus·Richik N MukherjeeDaniel L Levy
May 24, 2016·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Haiyan Huang, Qiang Wu
Apr 12, 2016·Current Opinion in Genetics & Development·Eric F JoyceC-Ting Wu
Sep 4, 2015·Genome Biology·Ferhat Ay, William S Noble
Nov 8, 2015·Biochemistry. Biokhimii︠a︡·O L KantidzeS V Razin
May 26, 2016·Seminars in Cell & Developmental Biology·Krysta L EngelDaniel Savic
Jun 12, 2016·Chromosoma·Sergey V Razin, Yegor S Vassetzky
Apr 20, 2016·Annual Review of Genomics and Human Genetics·Matthias Merkenschlager, Elphège P Nora
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Luay M AlmassalhaVadim Backman
Sep 11, 2016·Current Opinion in Plant Biology·Jun XiaoDoris Wagner
Nov 27, 2016·Journal of Cellular Physiology·Vibhuti Rana, Giovanni Bosco
May 21, 2016·PLoS Computational Biology·Raphaël Mourad, Olivier Cuvier
Jan 25, 2017·Evolution & Development·César Arenas-Mena
Apr 26, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Einari A Niskanen, Jorma J Palvimo
Apr 8, 2017·Cell·Peter Hugo Lodewijk Krijger, Wouter de Laat
Apr 20, 2017·Genome Research·Marc CorralesGuillaume J Filion
Jul 14, 2017·PLoS Genetics·Mohamed A El-Brolosy, Didier Y R Stainier
Mar 13, 2018·PLoS Genetics·Ezequiel NazerElissa P Lei
Oct 5, 2017·Nucleic Acids Research·Ravi BoyaJagan M R Pongubala
Mar 21, 2018·Nature Reviews. Genetics·Anniina VihervaaraJohn T Lis
Oct 14, 2017·PLoS Genetics·Jacqueline R WardMichelle S Longworth
Oct 11, 2017·Nature Structural & Molecular Biology·Hideki TanizawaKen-Ichi Noma

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.