PMID: 9437242Jan 23, 1998Paper

Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors

European Journal of Endocrinology
Y de KeyzerX Bertagna

Abstract

GH-releasing peptides are a new class of potent GH secretagogs (GHS) in vivo and in vitro. In normal man GHS also elicit low but definite ACTH and prolactin secretion. Recently it was shown that patients with pituitary corticotrope adenomas respond to GHS with a dramatic rise in ACTH secretion, and it has been suggested that GHS may provide a diagnostic tool to differentiate Cushing's disease from the ectopic ACTH syndrome. GHS actions are mediated by a G protein-coupled receptor recently characterized and cloned in man and rat. In this study we analyzed GHS receptor (GHS-R) expression in various types of pituitary adenoma and in endocrine and non-endocrine lung tumors by RT-PCR. GHS-R transcription was detected in all normal pituitaries and GH-secreting adenomas as expected. The receptor was also transcribed in some prolactin-secreting adenomas and non-functioning adenomas, and, more strikingly, in all 18 ACTH-secreting pituitary adenomas studied. Furthermore, it was frequently expressed in endocrine bronchial tumors, especially carcinoids, whereas it was not found or barely detectable in non-endocrine bronchial tumors. Again ACTH-secreting carcinoids of the lung were all positive for GHS-R expression. These results show that ...Continue Reading

Citations

May 15, 2002·European Journal of Pharmacology·Giampiero MuccioliEzio Ghigo
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E GhigoF Camanni
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M KorbonitsA B Grossman
Jun 25, 2014·Hypertension·Yuanjie MaoIchiro Kishimoto
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·M PapottiG Muccioli
Jun 8, 2004·Endocrine Reviews·Aart J van der LelyEzio Ghigo
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·S NielsenJ O Jørgensen
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jun 18, 2003·Journal of Endocrinological Investigation·J H A OliveiraA M J Lengyel
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony H YehLisa K Chopin

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