Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania

Emerging Infectious Diseases
Idrissa S ChumaSascha Knauf

Abstract

We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys). We found the bacterium at 11 of 14 investigated geographic locations. Anogenital ulceration was the most common clinical manifestation; orofacial lesions also were observed. Molecular data show that nonhuman primates in Tanzania are most likely infected with T. pallidum subsp. pertenue-like strains, which could have implications for human yaws eradication.

References

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Citations

Jan 21, 2020·American Journal of Physical Anthropology·Brenda J BakerStevie Winingear
Jul 6, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·David Mabey
May 23, 2020·Emerging Infectious Diseases·Benjamin MubembaFabian H Leendertz
Jan 23, 2019·Primates; Journal of Primatology·Thomas T StruhsakerAnja Landsmann
Mar 16, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Christopher BodimeadeDavid Mabey
Sep 20, 2018·Emerging Microbes & Infections·Sascha KnaufSébastien Calvignac-Spencer
Oct 19, 2019·Emerging Infectious Diseases·Dawn M ZimmermanSascha Knauf
Oct 31, 2020·Microbial Genomics·Benjamin MubembaSébastien Calvignac-Spencer
Nov 28, 2020·American Journal of Physical Anthropology·Christian RoosDietmar Zinner
May 6, 2020·New Microbes and New Infections·O MediannikovD Raoult
Sep 14, 2021·American Journal of Primatology·Anneke MorescoDalen W Agnew
Aug 5, 2021·Journal of Clinical Microbiology·Johanna M E VenterRanmini S Kularatne

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Methods Mentioned

BETA
PCR
biopsy

Software Mentioned

SeaView
GraphPad Prism
FreeCalc
Excel
ArcMap
4Peaks
GraphPad
StepOne
R

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