WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

Oncogene
Irene VassalloMonika E Hegi

Abstract

Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive nature cannot be completely removed. The WNT inhibitory factor 1 (WIF1), a secreted inhibitor of WNTs, is systematically downregulated in glioblastoma and acts as strong tumor suppressor. The aim of this study was the dissection of WIF1-associated tumor-suppressing effects mediated by canonical and non-canonical WNT signaling. We found that WIF1 besides inhibiting the canonical WNT pathway selectively downregulates the WNT/calcium pathway associated with significant reduction of p38-MAPK (p38-mitogen-activated protein kinase) phosphorylation. Knockdown of WNT5A, the only WNT ligand overexpressed in glioblastoma, phenocopied this inhibitory effect. WIF1 expression inhibited cell migration in vitro and in an orthotopic brain tumor model, in accordance with the known regulatory function of the WNT/Ca(2+) pathway on migration and invasion. In search of a mediator for this function differential gene expression profiles of WIF1-expressing cells were performed. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA and key positive regulator of invasion, emerged as the top downregulated gene. Indeed, knockdown of M...Continue Reading

References

Apr 1, 1997·Trends in Genetics : TIG·R T MoonM Torres
Feb 17, 2000·Cellular Signalling·K Ono, J Han
Apr 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Alissa K GreenbergTheodore C Lee
May 31, 2003·Journal of Cell Science·Yoshiaki Kawano, Robert Kypta
Jul 4, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Isao OishiYasuhiro Minami
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Mar 1, 2005·Oncogene·N KremenevskajaG Brabant
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Nov 15, 2006·The Journal of Cell Biology·Michiru NishitaYasuhiro Minami
Aug 9, 2007·The Journal of Biological Chemistry·Li Ma, Hsien-Yu Wang
Aug 22, 2007·Cancer Letters·Ji Min YuJin Sup Jung
Dec 28, 2007·Cell·Mikhail V SemenovXi He
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianming YingQian Tao
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anastasia MuratMonika E Hegi
Jul 18, 2008·Human Molecular Genetics·Mark LalMichael J Caplan
Aug 5, 2008·Neuro-oncology·Wolfgang WickUNKNOWN European Organisation for Research and Treatment of Cancer and the National Cancer Institute of Canada Clinical Trials Group
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jan 30, 2009·The Journal of Investigative Dermatology·Michael P O'ConnellAshani T Weeraratna
Aug 26, 2009·Communicative & Integrative Biology·Dana Chuderland, Rony Seger
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Davide SciuscioMonika E Hegi
Aug 6, 2011·Cancer Research·Benjamin G BitlerRugang Zhang
Sep 10, 2011·Acta Biochimica Et Biophysica Sinica·Antara De
Oct 13, 2011·Cancer Research·Teodoro PulvirentiAlan Hall
Mar 23, 2012·Cold Spring Harbor Perspectives in Biology·Paul Polakis
Jun 26, 2012·Nucleic Acids Research·Andreas UntergasserSteven G Rozen
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Nov 10, 2012·Cancer Research·Aihua Gong, Suyun Huang

❮ Previous
Next ❯

Citations

Jan 12, 2016·Molecular Neurobiology·Sukhleen Kour, Pramod C Rath
Mar 17, 2016·Journal of Neuropathology and Experimental Neurology·Abigail K SuwalaJaroslaw Maciaczyk
Sep 3, 2016·Epigenomics·Wallax Augusto Silva FerreiraBárbara do Nascimento Borges
Feb 16, 2016·International Journal of Cancer. Journal International Du Cancer·Sonam Dhamija, Sven Diederichs
Dec 5, 2017·Nucleic Acids Research·Sang-Soo KimEsther H Chang
Aug 18, 2018·Journal of Cellular and Molecular Medicine·Sevinci PopCristiana Tanase
Feb 9, 2018·Oncotarget·Liting YangZhaoyang Zeng
May 26, 2020·Journal of Cellular and Molecular Medicine·Chenyang XuSong Li
Jan 13, 2017·Topics in Magnetic Resonance Imaging : TMRI·Ahmed HassanPascal Olivier Zinn
Aug 23, 2019·Molecular Medicine Reports·Jianhua LiYazhuo Zhang
Jun 22, 2018·Oncology Letters·Miaomiao ZhaoXiaowei Liu
Jul 30, 2015·Journal of Neuropathology and Experimental Neurology·Ulf D KahlertCharles G Eberhart
Feb 6, 2017·Metabolic Brain Disease·Ye Chen, Jun Zhou
Nov 23, 2017·Cellular and Molecular Life Sciences : CMLS·Michaël H MeelEsther Hulleman
Feb 3, 2018·International Journal of Molecular Medicine·Longxiang TuDewu Liu
Sep 28, 2018·Neuromolecular Medicine·Marton TompaBernadette Kalman
Jan 19, 2019·Genes·Sorina DinescuMarieta Costache
Jan 16, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna M Krichevsky, Erik J Uhlmann
Sep 1, 2015·World Journal of Biological Chemistry·Keith Richard Mitchelson, Wen-Yan Qin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.