PMID: 8595677Feb 1, 1996Paper

Wild chromosomal variants in Aspergillus nidulans

Current Genetics
D M GeiserW E Timberlake

Abstract

Pulsed-field gel electrophoresis and a chromosome-specific cosmid DNA library were used to determine the karyotypes of wild-type Aspergillus nidulans isolates from around the world. Overall, little structural variation was found, with a few major exceptions. One isolate possessed a non-essential B-chromosome of about 1.0 million base pairs (mb). Another isolate had undergone a non-reciprocal translocation of about 1.6 mb of chromosome VI onto chromosome VIII. Other than these chromosomal differences, these isolates appeared phenotypically normal. To analyze its effects on meiosis, the translocation isolate was outcrossed with another wild-type derivative that had a normal electrophoretic karyotype. This cross produced a range of phenotypes, including duplicated progeny that had a barren phenotype similar to that described for Neurospora partial disomics. The duplication was somewhat vegetatively unstable. This is the first association of sterility with chromosomal duplication in A. nidulans.

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Citations

Nov 3, 2009·Genetica·Tatiana Aparecida VoltolinFabio Porto-Foresti
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J P CamachoL W Beukeboom
Jul 16, 2010·Hereditas·Tatiana Aparecida VoltolinFábio Porto-Foresti
May 26, 1999·Critical Reviews in Microbiology·F Fierro, J F Martín
Jan 9, 1999·Clinical Microbiology Reviews·J W TaylorV Koufopanou

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