PMID: 15357009Sep 11, 2004Paper

Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice

Archives of Pharmacal Research
Se Na YunSung Hyun Chung

Abstract

Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as 1920s. Although wild ginseng was anecdotally thought to be superior to cultivated ginseng as far as pharmacological properties were concerned, there have been no prior reports on the antidiabetic effect of wild ginseng. In this study, we investigated the preventative anti-diabetic and anti-obese effects of wild ginseng ethanol extract (WGEE). In the preventive experiment, WGEE co-administered with a high fat diet significantly inhibited body weight gain, fasting blood glucose, triglyceride, and free fatty acid levels in a dose dependent manner. WGEE-treated mice at doses of 250 and 500 mg/kg improved the insulin resistance index by 55% and 61% compared to the high fat diet (HFD) control, respectively. Diameters of white and brown adipocytes were also decreased by 62% and 46% in the WG500-treated group compared to those in HFD fed control mice. Taken together, WGEE has potential as a preventive agent for type 2 diabetes mellitus (and possibly obesity) and deserves clinical trial in the near future.

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 1, 1995·Diabetes Care·E A SotaniemiA Rautio
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Jun 22, 2000·Complementary Therapies in Medicine·J Barnes
Aug 10, 2000·The Journal of Clinical Investigation·M K CavaghanK S Polonsky
Oct 18, 2001·Journal of the American College of Nutrition·V VuksanM P Stavro
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Silvio E Inzucchi
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Valerie A AssineweJ Thor Arnason

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Citations

Apr 7, 2006·Archives of Pharmacal Research·Sang Hyun ParkSung Hyun Chung
Dec 6, 2011·Chinese Journal of Integrative Medicine·Sunmin ParkJames W Daily
Jul 24, 2012·Chinese Journal of Integrative Medicine·Neeru VasudevaSurendra Kumar Sharma
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·John Zeqi Luo, Luguang Luo
Jul 4, 2009·World Journal of Gastroenterology : WJG·Shirin Hasani-RanjbarMohammad Abdollahi
May 17, 2011·Indian Journal of Pharmacology·Shiv KumarM Raghavendra Rao
Jun 5, 2013·Cell Biochemistry and Biophysics·Ning LinJiao-Jiao Shi
Jan 23, 2016·International Journal of Molecular Sciences·Dorothy MosetiWoo-Kyun Kim
Mar 20, 2015·Drug Discoveries & Therapeutics·Wenwen RuYufeng Qin
Mar 11, 2016·BMC Complementary and Alternative Medicine·Min Chul KhoHo Sub Lee
Aug 11, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·William J BanzLaura Murphy
Oct 3, 2008·Phytotherapy Research : PTR·Mohammad Lalmoddin MollahKil-Soo Kim
Oct 29, 2011·Phytotherapy Research : PTR·Seo Hee LeeHyun Chul Lee
Aug 13, 2005·Journal of Ethnopharmacology·Sang Hyun ParkSung Hyun Chung
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jinbong ParkJae-Young Um
Aug 25, 2009·Biochemical and Biophysical Research Communications·Min KimKyong Soo Park
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Cicero L T ChangWen-Chin Yang
Nov 4, 2016·Nature Reviews. Endocrinology·Jan MartelJohn D Young
Oct 21, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew V Potenza, Jeffrey I Mechanick
Mar 8, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jin-Bo LiChun-Li Piao
Jan 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji-Won Yang, Sung Soo Kim
Jan 12, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chia-Rou YeoDavid G Popovich
Nov 6, 2018·Canadian Journal of Physiology and Pharmacology·Morris Karmazyn, Xiaohong Tracey Gan
Jul 10, 2007·Archives of Pharmacal Research·Se Na YunSung Hyun Chung
Feb 13, 2019·Cells·Young Jin JangSanguine Byun
Jan 8, 2008·Chemical & Pharmaceutical Bulletin·Jiang-Ning HuYi-Nan Zheng
May 11, 2017·International Journal of Molecular Medicine·Jae-Suk ChoiMi-Ryung Kim

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