Wild GWAS-association mapping in natural populations

Molecular Ecology Resources
Anna W Santure, Dany Garant

Abstract

The increasing affordability of sequencing and genotyping technologies has transformed the field of molecular ecology in recent decades. By correlating marker variants with trait variation using association analysis, large-scale genotyping and phenotyping of individuals from wild populations has enabled the identification of genomic regions that contribute to phenotypic differences among individuals. Such "gene mapping" studies are enabling us to better predict evolutionary potential and the ability of populations to adapt to challenges, such as changing environment. These studies are also allowing us to gain insight into the evolutionary processes maintaining variation in natural populations, to better understand genotype-by-environment and epistatic interactions and to track the dynamics of allele frequency change at loci contributing to traits under selection. Gene mapping in the wild using genomewide association scans (GWAS) do, however, come with a number of methodological challenges, not least the population structure in space and time inherent to natural populations. We here provide an overview of these challenges, summarize the exciting methodological advances and applications of association mapping in natural populatio...Continue Reading

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Citations

May 7, 2020·Molecular Ecology·Christine M BubacDavid W Coltman
May 19, 2020·Molecular Ecology Resources·Dave LutgenReto Burri
Jun 21, 2020·Molecular Ecology Resources·Belinda R WrightCatherine E Grueber
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Sep 19, 2019·Molecular Ecology·Gina M WimpMatthew B Hamilton
Jan 2, 2020·Evolutionary Applications·Richard C Hamelin, Amanda D Roe
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Sep 5, 2019·Frontiers in Genetics·Elvira Lafuente, Patrícia Beldade
Oct 25, 2020·Molecular Ecology Resources·José Luis Blanco-PastorJean-Paul Sampoux
Jan 29, 2021·Frontiers in Genetics·Alma KokhmetovaSusanne Dreisigacker
Feb 28, 2021·Molecular Ecology·S Eryn McFarlaneJosephine M Pemberton
Feb 1, 2021·Horticulture Research·Qiang LiYongrui He
Jul 1, 2021·Ecology and Evolution·Luis GarretaPaula H Reyes-Herrera
Sep 30, 2021·Proceedings. Biological Sciences·Lukas TietgenHenrik Jensen

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