Wild mice with different social network sizes vary in brain gene expression

BMC Genomics
Patricia C Lopes, Barbara König

Abstract

Appropriate social interactions influence animal fitness by impacting several processes, such as mating, territory defense, and offspring care. Many studies shedding light on the neurobiological underpinnings of social behavior have focused on nonapeptides (vasopressin, oxytocin, and homologues) and on sexual or parent-offspring interactions. Furthermore, animals have been studied under artificial laboratory conditions, where the consequences of behavioral responses may not be as critical as when expressed under natural environments, therefore obscuring certain physiological responses. We used automated recording of social interactions of wild house mice outside of the breeding season to detect individuals at both tails of a distribution of egocentric network sizes (characterized by number of different partners encountered per day). We then used RNA-seq to perform an unbiased assessment of neural differences in gene expression in the prefrontal cortex, the hippocampus and the hypothalamus between these mice with naturally occurring extreme differences in social network size. We found that the neurogenomic pathways associated with having extreme social network sizes differed between the sexes. In females, hundreds of genes were ...Continue Reading

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Methods Mentioned

BETA
RNA-seq
dissection

Software Mentioned

Heatmapper
R
STAR
HTSeq
ggplot2 R package
DESeq2 R package
rptR
DESeq2
clusterProfiler
ZEN

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