Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Josiana A VazIsabel C F R Ferreira

Abstract

The in vitro antioxidant and growth inhibitory activity of extracts obtained from two Portuguese wild mushrooms (Clitocybe alexandri and Lepista inversa) was studied in human tumour cell lines. The extracts were phenolic (methanolic and ethanolic) and polysaccharidic (boiling water). The antioxidant activity assays included evaluation of radical-scavenging capacity, reducing power and inhibition of lipid peroxidation measured in liposome solutions. Extract-induced cell growth inhibition was measured in four different tumour cell lines (lung, breast, colon and gastric cancer) using the SRB assay. The polysaccharidic extract of L. inversa was the most potent as antioxidant (EC(50)<1.8 ± 0.1mg/ml), while the phenolic ethanolic extract of C. alexandri was the most potent as inhibitor of growth of the studied cancer cell lines (GI(50)<26.0 ± 1.3 μg/ml). Together, these activities indicate that these mushrooms are promising sources of bioactive compounds.

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Citations

Apr 30, 2013·Bioorganic & Medicinal Chemistry·Carlos M G AzevedoMadalena M M Pinto
Jul 17, 2013·International Journal of Pharmaceutics·Ana M PaivaMadalena Pinto
Feb 9, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Filipa S ReisM Helena Vasconcelos
May 15, 2012·3 Biotech·Seema Patel, Arun Goyal
Mar 3, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Hugo J C FroufeIsabel C F R Ferreira
Apr 19, 2011·European Journal of Medicinal Chemistry·Marta Perro NevesMaria de São José Nascimento
Nov 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Filipa S ReisIsabel C F R Ferreira
Feb 17, 2015·International Journal of Microbiology·María Elena ValverdeOctavio Paredes-López
Oct 5, 2019·Antioxidants·Mikel Añibarro-OrtegaIsabel C F R Ferreira
Aug 7, 2012·Food & Function·Lu RenYacine Hemar
May 5, 2018·Natural Product Research·Urja PandyaNirmal S Sahay
Feb 19, 2014·International Journal of Oncology·Zainab M T JafaarCarolyn M Klinge

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