PMID: 11916039Mar 28, 2002Paper

Wild rats as monitors of environmental lead contamination in the urban area of Milan, Italy

Environmental Pollution
Roberta CerutiEugenio Scanziani

Abstract

Twenty-one wild brown rats (Rattus norvegicus) were collected from four areas of Milan (Italy). Main organs were harvested from each rat, fixed in 10% neutral buffer formalin, and embedded in paraffin. Organ sections were stained with hematoxylin and eosin, kidney sections were also stained with the Ziehl-Neelsen method. Graphite furnace atomic absorption spectrophotometry was performed on all kidney samples. The presence of inclusion bodies and karyocytomegaly was scored. Six adult rats out of 21 (28.6%) showed kariocytomegaly and intranuclear inclusion bodies of the renal proximal tubules, characteristic of lead toxicity. The nuclear inclusion bodies were always Ziehl-Neelsen positive. The six rats which showed the characteristic histological alterations ascribed to lead, had lead concentrations statistically higher than the three control rats (4 microg/g wet wt. versus 0.09 microg/g wet wt., P<0.001) and than the captured wild rats. Intranuclear inclusion bodies were found in rats with kidney lead concentrations greater than 0.6 microg/g wet weight. There were significant differences between the four areas of capture. The incidence of intranuclear inclusion bodies and karyocytomegaly in proximal tubular cells was higher in r...Continue Reading

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Citations

Mar 16, 2013·Archives of Environmental Contamination and Toxicology·Sachi TaniyasuNobuyoshi Yamashita
Oct 12, 2012·Environmental Monitoring and Assessment·Shouta M M NakayamaMayumi Ishizuka
Jul 19, 2008·Biological Trace Element Research·Ingrid CarruyoZaida Torrealba
Apr 19, 2011·Ecotoxicology and Environmental Safety·C FenoglioS Barni
Sep 1, 2015·Reproductive Toxicology·Piotr RzymskiPiotr Dąbrowski
Jan 9, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mahmoud Shaban El-Neweshy, Yasser Said El-Sayed
Oct 26, 2010·Environmental Pollution·Shouta M M NakayamaMayumi Ishizuka
Feb 18, 2014·The Science of the Total Environment·Michele ArdizzoneElena Belluso
Mar 29, 2007·Radiation Research·Marie Donnadieu-ClarazPatrick Gourmelon
May 20, 2016·Iranian Red Crescent Medical Journal·Mohammad Hassan KarimfarParviz Farzadinia
Mar 12, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jamie L RothenburgerClaire M Jardine
Jan 12, 2017·International Journal of Environmental Research and Public Health·Hokuto NakataMayumi Ishizuka
Nov 2, 2020·Environmental Research·Ronnie LevinMary Jean Brown

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