Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp.

Journal of Clinical Microbiology
Michael PfallerDaniel Diekema

Abstract

We tested a global collection of Candida sp. strains against anidulafungin, caspofungin, and micafungin, using CLSI M27-A3 broth microdilution (BMD) methods, in order to define wild-type (WT) populations and epidemiological cutoff values (ECVs). From 2003 to 2007, 8,271 isolates of Candida spp. (4,283 C. albicans, 1,236 C. glabrata, 1,238 C. parapsilosis, 996 C. tropicalis, 270 C. krusei, 99 C. lusitaniae, 88 C. guilliermondii, and 61 C. kefyr isolates) were obtained from over 100 centers worldwide. The modal MICs (in microg/ml) for anidulafungin, caspofungin, and micafungin, respectively, for each species were as follows: C. albicans, 0.03, 0.03, 0.015; C. glabrata, 0.06, 0.03, 0.015; C. tropicalis, 0.03, 0.03, 0.015; C. kefyr, 0.06, 0.015, 0.06; C. krusei, 0.03, 0.06, 0.06; C. lusitaniae, 0.05, 0.25, 0.12; C. parapsilosis, 2, 0.25, 1; and C. guilliermondii, 2, 0.5. 05. The ECVs, expressed in microg/ml (percentage of isolates that had MICs that were less than or equal to the ECV is shown in parentheses) for anidulafungin, caspofungin, and micafungin, respectively, were as follows: 0.12 (99.7%), 0.12 (99.8%), and 0.03 (97.7%) for C. albicans; 0.25 (99.4%), 0.12 (98.5%), and 0.03 (98.2%) for C. glabrata; 0.12 (98.9%), 0.12 (99.4...Continue Reading

References

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Citations

Mar 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara D AlexanderMichael A Pfaller
Dec 12, 2012·The Journal of Antimicrobial Chemotherapy·Emilia CantónAna Espinel-Ingroff
Sep 15, 2010·Antimicrobial Agents and Chemotherapy·Alicia J ZimbeckShawn R Lockhart
Mar 24, 2010·Antimicrobial Agents and Chemotherapy·William W HopeDaniel K Benjamin
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraMichael A Pfaller
May 6, 2011·Journal of Clinical Microbiology·Marlene Axner-ElingsMaiken Cavling Arendrup
Apr 15, 2011·Journal of Clinical Microbiology·Marie Desnos-OllivierFrançoise Dromer
Feb 5, 2010·Journal of Clinical Microbiology·G Marshall LyonUNKNOWN Candida Surveillance Study Investigators
Apr 30, 2011·Future Microbiology·David S Perlin
Sep 28, 2014·International Journal of Antimicrobial Agents·Tan N DoanCarl M J Kirkpatrick
Apr 12, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E BorghiG Morace
Sep 13, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L A Vale-SilvaE Pinto
Sep 16, 2015·Critical Reviews in Microbiology·Jessica C Song, David A Stevens
Jan 27, 2016·Mycoses·Sarah Santos GonçalvesArnaldo Lopes Colombo
Dec 19, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Mar 1, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·M A PfallerUNKNOWN CLSI Subcommittee for Antifungal Testing
Nov 6, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·M A PfallerUNKNOWN CLSI Subcommittee for Antifungal Susceptibility Testing
Jan 8, 2016·Infectious Disease Clinics of North America·Todd P McCarty, Peter G Pappas

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