Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

doi:10.1016/j.nbd.2019.104648

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease

Oct 30, 2019

Yue-Qing YangHong-Lin Feng

PMID: 31676238

DOI: 10.1016/j.nbd.2019.104648

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Abstract

Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that terminates DNA-damage responses via deph...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis

Cell Survival

DNA Damage

DNA Repair

Down-Regulation

Laboratory mice

Motor Neurons

Protein phosphatase

Phosphotransferases

Protein KINASE

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Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Abstract