Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

doi:10.1016/j.nbd.2019.104648

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease

Nov 5, 2019

Yue-Qing YangHong-Lin Feng

PMID: 31676238

DOI: 10.1016/j.nbd.2019.104648

Abstract

Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that terminates DNA-damage responses via deph...read more

Mentioned in this Paper

superoxide dismutase 1

In Vivo

DNA Repair

Ubiquitin

Response to DNA Damage Stimulus

Motor Neurons

HIPK2

PPM1D gene

Amyotrophic Lateral Sclerosis

TP53

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Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Abstract