journal cover

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease

Oct 30, 2019

Yue-Qing YangHong-Lin Feng

Get paper from

Abstract

Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that terminates DNA-damage responses via deph...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Cell Survival
DNA Damage
DNA Repair
Down-Regulation
Laboratory mice
Motor Neurons
Protein phosphatase
Phosphotransferases
Protein KINASE
1
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Neuromuscular Disorders

Neuromuscular disorders result in impaired functioning of the muscles. Discover the latest research on these disorders, including ALS, and the underlying genetic aspects here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma is a highly aggressive pediatric brainstem tumor with a peak incidence in middle childhood and a median survival of less than 1 year. Here is the latest research.

Sonic Hedgehog Signaling

The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

p53 Pathway

p53 is a transcription factor that is involved in several cellular processes, including cell cycle arrest, cellular apoptosis, cell death and cell senescence. Mutations in the wild type p53 gene has been implicated in a significant number of cancers. Here is the latest research on p53 pathways.

Motor Neuron Disease

Motor neuron diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy are progressive neurodegenerative diseases that result in the death of motor neurons. Discover the latest research on motor neuron disease here.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

Ubiquitin System

Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.

Neuronal Cell Types

There are diverse ranges of neurons, which are defined by their structural, functional, connectional and molecular properties. For example, some type of neurons includes sensory, sympathetic, and motor neurons. Discover the latest research on neuronal cell types here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2019 Meta ULC. All rights reserved

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

Neurobiology of Disease

Oct 30, 2019

Yue-Qing YangHong-Lin Feng

PMID: 31676238

DOI: 10.1016/j.nbd.2019.104648

Abstract

Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that terminates DNA-damage responses via deph...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Cell Survival
DNA Damage
DNA Repair
Down-Regulation
1
1

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/wild-type-p53-induced-phosphatase-1-down-regulatio/31676238