Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?

Journal of Chemical Information and Modeling
Luciano A Abriata, Matteo Dal Peraro

Abstract

Protein dynamics is undoubtedly a pervasive ingredient in all biological functions. However, structural biology has been strongly driven by a static-centered view of protein architecture. We argue that the recent advances of cryo-electron microscopy (EM) have the potential to more broadly explore the conformational landscapes of protein complexes and therefore will enhance our ability to predict the diverse conformations of tertiary and quaternary protein structures that are functionally relevant in physiological conditions.

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·Subash C PakhrinDukka B Kc
May 27, 2020·Journal of Chemical Information and Modeling·Giulia PalermoRommie E Amaro

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