PMID: 9425654Jan 13, 1998Paper

Will genetics really revolutionize the drug discovery process?

Current Opinion in Biotechnology
L M Gelbert, R E Gregg

Abstract

Genetics has played only a modest role in drug discovery, but new technologies will radically change this. Whole genome sequencing will identify new drug discovery targets, and emerging methods for the determination of gene function will increase the ability to select robust targets. Detection of single nucleotide polymorphisms and common polymorphisms will enhance the investigation of polygenic diseases and the use of genetics in drug development. Oligonucleotide arraying technologies will allow analysis of gene expression patterns in novel ways.

References

Jun 21, 1991·Science·L Roberts
Jul 28, 1995·Science·R D FleischmannJ M Merrick
Jul 28, 1995·Science·R Nowak
Apr 1, 1995·Nature Genetics·F S Collins
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·A C PeaseS P Fodor
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Smith, P Modrich
Jul 1, 1996·Nature Genetics·P HieterD Valle
Aug 23, 1996·Science·V Morell
Sep 13, 1996·Science·N Risch, K Merikangas
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·M VidalJ D Boeke
Oct 25, 1996·Science·G D SchulerT J Hudson
Oct 25, 1996·Science·A GoffeauS G Oliver
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis
Nov 8, 1996·Science·M R Emmert-BuckL A Liotta
Sep 1, 1996·Genome Research·L D HillierM Marra
Oct 25, 1996·Science·E S Lander
Nov 29, 1996·Science·S B ShukerS W Fesik
Nov 1, 1996·Journal of Chemical Information and Computer Sciences·Z LuoL Lai
Dec 1, 1996·Nature Genetics
Dec 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Gerhold, C T Caskey
Aug 1, 1996·Trends in Biotechnology·A Lyall
Feb 7, 1997·Science·J Cohen
Mar 1, 1997·Genome Research·D T BurkeC Mastrangelo
Apr 1, 1997·Current Opinion in Structural Biology·R Sánchez, A Sali
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R A HellerR W Davis
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·U A Meyer, U M Zanger
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·A R MushegianE V Koonin
May 29, 1997·Nature·R A ClaytonJ C Venter
Jul 1, 1997·Nature Genetics·M A Ansari-LariR A Gibbs
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·F RossiH M Blau
Sep 5, 1997·Science·F R BlattnerY Shao
Aug 29, 1997·Science·D BotsteinJ M Cherry
Dec 1, 1996·Nature Biotechnology·A P Blanchard, L Hood
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Sep 10, 1999·International Journal for Parasitology·D C HoltK R Trenholme

❮ Previous
Next ❯

Citations

May 30, 2001·Drug Discovery Today·J C. Chamberlain, P H. Joubert
Sep 7, 2000·Microbiology and Molecular Biology Reviews : MMBR·A T BullM Goodfellow
Oct 29, 1998·Journal of Molecular Biology·P BorkY Yuan
Mar 18, 2004·Bioconjugate Chemistry·Martin R DeibelAtli Thorarensen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.