Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)

Frontiers in Immunology
David S KimEster Gea-Mallorquí

Abstract

In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China resulted in the current COVID-19 global pandemic. The human immune system has not previously encountered this virus, raising the important question as to whether or not protective immunity is generated by infection. Growing evidence suggests that protective immunity can indeed be acquired post-infection-although a handful of reinfection cases have been reported. However, it is still unknown whether the immune response to SARS-CoV-2 leads to some degree of long-lasting protection against the disease or the infection. This review draws insights from previous knowledge regarding the nature and longevity of immunity to the related virus, SARS-CoV, to fill the gaps in our understanding of the immune response to SARS-CoV-2. Deciphering the immunological characteristics that give rise to protective immunity against SARS-CoV-2 is critical to guiding vaccine development and also predicting the course of the pandemic. Here we discuss the recent evidence that characterises the adaptive immune response against SARS-CoV-2 and its potential implications for the generation of memory responses and long-term protection.

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Mar 2, 2021·Annals of Internal Medicine·Brit Trogen, Arthur Caplan
Feb 28, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Eskild PetersenLin H Chen
Apr 20, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Torsten HansenLudwig Wilkens
May 16, 2021·Oral Diseases·Lakshman Perera SamaranayakeKausar Sadia Fakhruddin
Jun 1, 2021·Diagnostic Microbiology and Infectious Disease·Anneleen SchallierPedro Couck

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
bronchoalveolar lavage
glycosylation
RNA-seq

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