PMID: 2493718Jan 1, 1989Paper

Will the "short dialysis" of the eighties be adequate?

Advances in Nephrology From the Necker Hospital
C Jacobs

Abstract

Almost 30 years have elapsed since the first successful attempts by Scribner and his associates of the Seattle Group to sustain life for an unlimited period of time in patients with end-stage renal failure. More than 250,000 patients are currently treated worldwide with various methods of maintenance dialysis, with survival rates reaching 75% at 10 years and 65% at 15 years reported by experienced groups. Such results are all the more remarkable (and initially unexpected) both because maintenance hemodialysis can replace only partially the numerous sophisticated regulatory functions of the normal kidney and despite our persistent ignorance of many factors involved in uremic toxicity. Moreover, an entirely new, multifaceted pathology has developed in the population of patients submitted to long-term hemodialysis as a consequence of the permanently incomplete correction of the uremic syndrome together with the multiple disorders and complications induced by dialysis and its related therapeutic procedures. In this context, the key question concerning the optimal duration of hemodialysis required to provide patients with a life as close to normal as possible, and in the highest conditions of safety and comfort, remains a matter of ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.