Will we ever find the genes for addiction?

Addiction
Paul R Buckland

Abstract

To assess the likelihood of finding genes which predispose to addiction and to present this information in a form accessible to the general readership of Addiction. Review of the evidence that genetic factors play a significant role in the process of addiction and the proximity of the identification of these factors. The search for the genetic susceptibility variants for many complex illnesses has been ongoing for decades, with increased pace in the last 20 years. However, until very recently only a small number of such variants have been found. Recent studies have used several thousand samples in genome-wide association studies and the latest genotyping technology and have reported a growing number of successes, but have highlighted the need for even larger samples and new statistical methods or new experimental approaches to identify fully the genes involved in the disease process. The phenotype for addiction to drugs is not well defined, and the heritability of addiction to drugs of abuse is far from clear and may be small compared to that of many other complex disorders. The absolute requirement for the administration of drugs before addiction can occur, and other environmental factors known to have a major effect, makes th...Continue Reading

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Citations

May 27, 2009·Addiction·Carmen S van der Zwaluw, Rutger C M E Engels
Jan 28, 2010·Alcoholism, Clinical and Experimental Research·Nicoletta OnoriAdriano Tagliabracci
Jan 17, 2019·Current Clinical Pharmacology·Masoud Latifi-PourMitra Rahimi

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