Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?

Frontiers in Pharmacology
Federica GilardiAurelien Thomas

Abstract

A growing number of evidence demonstrates that ancestral exposure to xenobiotics (pollutants, drugs of abuse, etc.) can perturb the physiology and behavior of descendants. Both maternal and paternal transmission of phenotype across generations has been proved, demonstrating that parental drug history may have significant implications for subsequent generations. In the last years, the burden of novel synthetic opioid (NSO) consumption, due to increased medical prescription of pain medications and to easier accessibility of these substances on illegal market, is raising new questions first in term of public health, but also about the consequences of the parental use of these drugs on future generations. Besides being associated to the neonatal abstinence syndrome, in utero exposure to opioids has an impact on neuronal development with long-term repercussions that are potentially transmitted to subsequent generations. In addition, recent reports suggest that opioid use even before conception influences the reactivity to opioids of the progeny and the following generations, likely through epigenetic mechanisms. This review describes the current knowledge about the transgenerational effects of opioid consumption. We summarize the pr...Continue Reading

References

Apr 1, 1993·The American Journal of Orthopsychiatry·M M de Cubas, T Field
Oct 17, 1998·European Journal of Pediatrics·R BunikowskiM Obladen
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Feb 7, 2006·Neurotoxicology and Teratology·Fang HeMichael S Lidow
Sep 30, 2006·Fertility and Sterility·Maria AlbrizioPaolo Minoia
Aug 31, 2007·Early Human Development·Rod W HuntHeather E Jeffery
Sep 18, 2007·Behavioural Brain Research·Alireza SarkakiNaser Pajouhi
Jul 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A NielsenMary Jeanne Kreek
Sep 18, 2009·Genes & Development·Marisa S Bartolomei
Feb 23, 2010·Developmental Psychobiology·Frances A Champagne
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
Mar 24, 2010·Behavioural Brain Research·Chris P DavisLisa M Schrott
Jan 20, 2011·Clinical Chemistry·Ana de CastroMarilyn A Huestis
Mar 8, 2011·American Journal of Obstetrics and Gynecology·Ann KelloggWilliam J Watson
Jun 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Michael K Skinner
Aug 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P Morgan, Tracy L Bale
Oct 1, 2011·Journal of Opioid Management·Vesselin M ChorbovTheodore J Cicero
Mar 16, 2012·Reproductive Biomedicine Online·Ekaitz AgirregoitiaNaiara Agirregoitia
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haosheng SunEric J Nestler
Dec 18, 2012·Nature Neuroscience·Fair M VassolerR Christopher Pierce
Jan 15, 2013·Psychopharmacology·John J ByrnesElizabeth M Byrnes
Mar 7, 2013·Nature Structural & Molecular Biology·Yehudit Bergman, Howard Cedar
May 2, 2013·JAMA : the Journal of the American Medical Association·Elisha M WachmanJonathan M Davis
May 30, 2013·PLoS Genetics·Jafar KianiMinoo Rassoulzadegan
Oct 1, 2013·Pharmacological Reviews·Gavril W Pasternak, Ying-Xian Pan
Dec 11, 2013·Toxicology Letters·Chih-Cheng WuChun-Jung Chen
Dec 25, 2013·PloS One·Chih-Jen HungChun-Jung Chen

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Methods Mentioned

BETA
acetylation
histone acetylation

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