PMID: 9194063May 1, 1997Paper

Williams syndrome as a model of genetically determined right-hemisphere dominance

Neuroscience and Behavioral Physiology
N N Bogdanov, V G Solonichenko

Abstract

Studies were carried out on the dermatoglyphics (skin ridge marks) on the hands of children with Williams syndrome; this is an inherited disease with cardiovascular pathology and a characteristic facial phenotype ("elf" facies), along with specific mental and cognitive disturbances. The results suggest a characteristic dermatoglyphic type with the presence of complex whorls on the fingers and a clear predominance of marks of greater complexity on the left hand; this is a very rare trait in normal people and in those with other inherited nervous system disorders. The features of the dermatoglyphic pattern serve as a characteristic marker of a genetically determined state of the human central nervous system, and suggests directions for neurophysiological studies of children with Williams syndrome as a unique model for analysis of higher nervous function in humans.

References

Jul 12, 1968·Science·N Geschwind, W Levitsky
Jun 1, 1929·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Kristine Bonnevie

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