Wilms tumor: Successes and challenges in management outside of cooperative clinical trials

Hematology/oncology and Stem Cell Therapy
Wissam RabehRaya Saab

Abstract

Management of Wilms tumor (WT) in children depends on a multidisciplinary approach to treatment, and outcomes have significantly improved as reported by cooperative group clinical trials. Here, we review the clinical outcomes of patients with WT and identify challenges and barriers encountered in multidisciplinary management outside of cooperative clinical trials. We retrospectively reviewed the clinical records of 35 children with WT treated between April 2002 and June 2013 at the Children's Cancer Institute in Lebanon. Upfront resection was performed in 23 cases. Biopsies were performed for Stage V tumors (n=4), those with unresectable tumors or inferior vena caval thrombus (n=5), and patients who had partial surgery performed elsewhere prior to presentation (n=2). One patient died due to toxicity prior to surgery. The tumor was Stage I in eight patients, Stage II in five patients, Stages III and IV in nine patients each, and bilateral (Stage V) in four patients. Adherence to The National Wilms Tumor Study-5 recommendations was adequate. At the time of analysis, 30 patients were free of disease and four patients had relapse-all having metastatic disease initially. The National Wilms Tumor Study-5 therapy resulted in favorable...Continue Reading

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Citations

Nov 19, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wai Chin Chong, Jason E Cain
Mar 24, 2020·Pediatric Hematology and Oncology·Christine KongstadAnne-Mette Hvas
Aug 15, 2020·Journal of the Egyptian National Cancer Institute·Hosam Y AsfourWael Zekri
May 7, 2020·Journal of the Egyptian National Cancer Institute·Moatasem ElayadiWael Zekri

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