Wilms Tumor Treatment Outcomes: Perspectives From a Low-Income Setting

Journal of Global Oncology
Festus NjugunaSaskia Mostert

Abstract

Wilms tumor is the commonest renal malignancy in childhood. Survival in high-income countries is approximately 90%, whereas in low-income countries, it is less than 50%. This study assessed treatment outcomes of patients with Wilms tumor at a Kenyan academic hospital. We conducted a retrospective medical record review of all children diagnosed with Wilms tumor between 2010 and 2012. Data on treatment outcomes and various sociodemographic and clinical characteristics were collected. Of the 39 patients with Wilms tumor, 41% had event-free survival, 31% abandoned treatment, 23% died, and 5% had progressive or relapsed disease. Most patients presented at an advanced stage: stage I (0%), II (7%), III (43%), IV (40%), or V (10%). The most likely treatment outcome in patients with low-stage (I to III) disease was event-free survival (67%), whereas in those with high-stage (IV to V) disease, it was death (40%). No deaths or instances of progressive or relapsed disease were recorded among patients with low-stage disease; their only reason for treatment failure was abandonment of treatment. Stage of disease significantly affected treatment outcomes (P = .014) and event-free survival estimates (P < .001). Age at diagnosis, sex, duration o...Continue Reading

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Citations

Sep 22, 2018·Pediatric Hematology and Oncology·Trijn IsraelsElizabeth Molyneux
Jun 28, 2020·Cancer Medicine·Ana Carolina Kerekes MiguezDirce Maria Carraro
Sep 6, 2019·Journal of Global Oncology·Atteby Jean-Jacques YaoCatherine Patte
May 7, 2020·Journal of the Egyptian National Cancer Institute·Moatasem ElayadiWael Zekri
Feb 13, 2021·Journal of Pediatric Surgery·Henry DrysdaleKokila Lakhoo
Mar 16, 2021·Pediatric Blood & Cancer·Glenn Mbah AfungchwiPeter B Hesseling
Jun 12, 2021·BMC Urology·Senai Goitom SerekeFelix Bongomin
Nov 24, 2021·Cancer Reports·Romy E van WeelderenGertjan J L Kaspers
Dec 16, 2021·Pediatric Blood & Cancer·Aniek UittenboogaardGertjan J L Kaspers

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