Wilson disease

Current Opinion in Neurology
Annu Aggarwal, Mohit Bhatt

Abstract

The aim of this article is to review recent developments in the areas of the disease features and treatment of Wilson disease, and survey disorders that share its pathophysiology or clinical symptoms. Knowledge of the clinical spectrum of Wilson disease has expanded with recognition of patients who present in atypical age groups - patients with very early onset (<5 years) and those in whom symptoms present in mid-to-late adulthood. A disease phenotype with dominant psychiatric features and increased risk of cardiac problems and various sleep disorders have been identified.In addition to a better understanding of the phenotype of Wilson disease itself, features of some related disorders ('Wilson disease-mimics') have been described leading to a better understanding of copper homeostasis in humans. These disorders include diseases of copper disposition, such as mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratoderma syndrome, Niemann-Pick type C, and certain congenital disorders of glycosylation, as well as analogous disorders of iron and manganese metabolism.Outcomes for existing treatments, including in certain patient subpopulations of interest, are better known. Novel treatment strategies being studied ...Continue Reading

References

Nov 4, 2000·The Journal of Pediatrics·D C WilsonE A Roberts
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aftab AlaMichael Schilsky
Apr 17, 2007·Gastroenterology·Peter FerenciWolfgang Stremmel
Mar 4, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anna CzłonkowskaGrazyna Gromadzka
Feb 21, 2013·Brain : a Journal of Neurology·Diego MartinelliCarlo Dionisi-Vici
Jun 29, 2014·Clinics and Research in Hepatology and Gastroenterology·Piotr SochaStuart Tanner
Aug 15, 2014·Arquivos de neuro-psiquiatria·Gotthard G TriblEgberto R Barbosa
Aug 28, 2014·Journal of Gastroenterology and Hepatology·Suzanne van MeerKarel J van Erpecum
Nov 5, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Jan PfeiffenbergerKarl Heinz Weiss
Dec 18, 2014·World Journal of Gastroenterology : WJG·Ella WeitzmanZiv Ben Ari
Jan 22, 2015·Digestive Diseases and Sciences·Aftab AlaMichael L Schilsky
Mar 18, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Marialuisa QuadriVincenzo Bonifati
Apr 29, 2015·Journal of Hepatology·Stuart J ForbesAnil Dhawan
Aug 5, 2015·The Journal of Clinical Investigation·Clavia Ruth Wooton-KeeDavid D Moore
Sep 27, 2015·Journal of Hepatology·Oihana MurilloGloria Gonzalez-Aseguinolaza
Dec 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giancarlo ChesiRoman S Polishchuk
Dec 19, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James P HamiltonSvetlana Lutsenko
Jan 15, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Madhu NagappaArun B Taly
Mar 5, 2016·Acta Neurologica Scandinavica·M C TrindadeG G Tribl
Jun 21, 2016·The Journal of Clinical Investigation·Josef LichtmanneggerHans Zischka
Apr 22, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Abigael MuchenditsiSvetlana Lutsenko
Jul 29, 2017·Journal of Pediatric Gastroenterology and Nutrition·Anna WiernickaPiotr Socha
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jan PfeiffenbergerKarl Heinz Weiss
Sep 28, 2017·The American Journal of Cardiology·Donald J GrandisGregory M Marcus
Oct 29, 2017·European Journal of Medical Genetics·Romain PéanneJaak Jaeken
Dec 5, 2017·Indian Journal of Psychological Medicine·Forouzan Elyasi
Jan 30, 2018·World Journal of Gastroenterology : WJG·Takahiro AmanoMasami Inada
Mar 6, 2018·Parkinsonism & Related Disorders·Sara PelucchiAlberto Piperno
May 29, 2018·Expert Opinion on Investigational Drugs·Karl Heinz WeissPeter Ferenci
Jun 14, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jennifer-Christin MüllerUwe Karst
Jun 28, 2018·Genes & Development·Navasona KrishnanNicholas K Tonks
Jul 7, 2018·Therapeutic Advances in Psychopharmacology·Tomasz LitwinJanusz K Rybakowski
Aug 2, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pan-Woo KoHo-Won Lee
Oct 3, 2018·Journal of Neurosciences in Rural Practice·Bhupendra Shah, Suren Limbu
Nov 7, 2018·Current Gastroenterology Reports·Eve A Roberts
Dec 19, 2018·The Ochsner Journal·Renée V Gardner
Jan 30, 2019·Orphanet Journal of Rare Diseases·Silvio QuickUwe Speiser
Apr 27, 2019·Frontiers in Neuroscience·Giacomo MarchiDomenico Girelli
May 16, 2019·Current Neurology and Neuroscience Reports·S Anagianni, K Tuschl
Jun 11, 2019·Annals of Translational Medicine·Ulrike Reuner, Juergen Dinger
Jun 12, 2019·Clinical Case Reports·Mehdi YousefiAnneh M Gharravi
Jul 31, 2019·Archives of Medical Science : AMS·Małgorzata Buksińska-LisikAnna Członkowska
Aug 20, 2019·General Psychiatry·Margarita Guerrero-JiménezLuis Gutierrez Rojas

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