'Wind-up' in Parkinson's disease: A functional magnetic resonance imaging study

European Journal of Pain : EJP
Z AschermannG Orsi

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder mainly marked by selective degeneration of dopaminergic neurons that leads to disabling motor and cognitive impairment. This condition is less widely appreciated as a disease associated with a substantial variety of pain syndromes, although the prevalence of pain is relatively high. Repeated painful stimulation of peripheral nerves can cause pain 'wind-up' if the frequency of the stimulation is adequate and specifically stimulates the afferent C-fibres. We presumed that in case of PD, pain or pain severeness might be frequently caused by the aggravation of the 'wind-up' phenomenon due to any central or peripheral lesions or functional alterations. To test for this hypothesis, we compared three groups (patients with left- and right-dominant PD and control subjects) using functional magnetic resonance imaging and thermally induced pain. Patient showed higher average 'wind-up' scores, compared to the healthy subjects, with lower values on the more affected sides compared to the less affected ones. In group level comparisons, patients had higher activation during 'wind-up' compared to control subjects in two main areas; these were the posterior division of cingulate gyrus and...Continue Reading

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Citations

Jul 12, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Katharina Klatt-SchreinerIrmgard Tegeder
Jan 7, 2021·Journal of Pain Research·Yenisel Cruz-AlmeidaCatherine C Price

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