Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila

Current Biology : CB
T KleinA Martinez Arias

Abstract

The development and patterning of the Drosophila wing relies on interactions between cell populations that have the anteroposterior (AP) axis and dorsoventral (DV) axis of the wing imaginal disc as frames of reference [1-3]. Each of these cell populations gives rise to a compartment - a group of cells that have their fates restricted by cell lineage - within which cells acquire specific identities through the expression of 'selector' genes [1,2,4]. The genes engrailed (en) and invected (inv), for example, label cells in the posterior compartment and mediate a set of cell interactions that direct the patterning and growth of the wing along the AP axis [1,2,4]. A similar situation has been proposed to exist across the DV axis, along with apterous (ap) as a dorsal selector gene [5], mediating cell interactions by regulating the expression of Serrate (Ser) [6] [7] and fringe (fng) [8]. In ap mutants, the wing is lost [5] [9], and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates.

References

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Citations

Dec 17, 2009·Current Biology : CB·Yoshinori TomoyasuRobin E Denell
Oct 8, 2011·PLoS Computational Biology·Oriol Canela-XandriJavier Buceta
May 6, 2010·PloS One·Veronika SanderEdward M De Robertis
Jun 29, 2011·Developmental Biology·Nataliya TurchynAleksandar Popadić
Oct 8, 2004·Developmental Cell·Catherine A KirkpatrickScott B Selleck
Feb 24, 2007·The International Journal of Biochemistry & Cell Biology·Kimberly D McClure, Gerold Schubiger
Jun 22, 2011·Biochemical Pharmacology·Alexey KovalVladimir L Katanaev
Sep 23, 2003·Nature Cell Biology·Sophie PantalacciPierre Léopold
Nov 26, 2002·Nature Cell Biology·Julia A KaltschmidtAlfonso Martinez Arias
Apr 4, 2015·G3 : Genes - Genomes - Genetics·Dimitri BieliMartin Müller

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