Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development

Development
Antonio J Giraldez, Stephen M Cohen

Abstract

Tissue growth during animal development depends on the coordination of cell proliferation and cell death. The EGF-receptor/MAPK, Hedgehog, Dpp, Wingless (Wg) and Notch signaling pathways have been implicated in growth control in the developing Drosophila wing. In this report, we examine the effects of Notch and Wg on growth in terms of cell proliferation and cell survival. Reduction of Wg signaling impaired compartment and clonal growth, and increased cell death. Inhibition of apoptosis in cells deficient for Wg signaling only partially rescued the clone growth defect, suggesting that Wg is also required to promote cell proliferation. This is supported by the finding that ectopic expression of Wg caused over-proliferation of cells in the proximal wing. Localized activation of Notch had non-autonomous effects on cell proliferation. However, only part of this effect was attributable to Notch-dependent induction of Wg, suggesting that other Notch-inducible signaling molecules contribute to the control of cell proliferation in the wing.

Citations

Jul 22, 2005·Nature Reviews. Cancer·Anthony M Brumby, Helena E Richardson
Apr 22, 2011·Nature Reviews. Cancer·Prathibha RanganathanAnthony J Capobianco
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·David R Hipfner, Stephen M Cohen
Mar 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Verónica RodillaLluís Espinosa
Jul 20, 2007·Molecular Biology of the Cell·Sabrina J Kugler, Anja C Nagel
Oct 8, 2009·Science Signaling·Luis Alberto Baena-LopezJean-Paul Vincent
Oct 14, 2004·Science's STKE : Signal Transduction Knowledge Environment·Sharad Kumar
Sep 27, 2006·Molecular and Cellular Biology·Maria BalakirevaJacques Camonis
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Ricardo M Neto-SilvaLaura A Johnston
Dec 14, 2007·Annual Review of Genetics·Jason Pellettieri, Alejandro Sánchez Alvarado
Oct 5, 2013·BMC Biology·Nikolaos DoumpasAurelio A Teleman
Oct 8, 2011·PLoS Computational Biology·Oriol Canela-XandriJavier Buceta
Jan 7, 2014·Nature·Cyrille AlexandreJean-Paul Vincent
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luis Alberto Baena-LopezAntonio Baonza
Sep 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Luis Alberto Baena-Lopez, A García-Bellido
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lars HufnagelBoris I Shraiman
Mar 4, 2014·Seminars in Cell & Developmental Biology·Graham P Bell, Barry J Thompson
May 27, 2014·Apoptosis : an International Journal on Programmed Cell Death·Rocío SimónAna Busturia
Mar 1, 2005·Oncogene·Tina MukherjeeMartin P Zeidler
Mar 20, 2013·The Journal of Cell Biology·Romain Levayer, Eduardo Moreno
Jul 1, 2009·The Journal of Cell Biology·Antonio J Giraldez
Jan 20, 2012·Current Opinion in Cell Biology·Luis Alberto Baena-LopezJean-Paul Vincent
Nov 1, 2011·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yoichiro Tamori, Wu-Min Deng
Nov 6, 2015·Cellular & Molecular Biology Letters·Manish PatelNeeta Shrivastava
Dec 4, 2015·Annual Review of Genetics·Rajan GognaEduardo Moreno
Jul 13, 2007·Current Opinion in Genetics & Development·Nicholas E Baker
Feb 24, 2007·Current Opinion in Cell Biology·Gregory D HurlbutSpyros Artavanis-Tsakonas
Jul 26, 2005·Journal of Neurobiology·Patrick MehlenChantal Thibert
Aug 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Penelope HaywardAlfonso Martinez Arias
Mar 23, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Simon de BecoLaura A Johnston
Dec 13, 2012·The EMBO Journal·Alexandre DjianeSarah J Bray
Nov 9, 2010·Mechanisms of Development·David D O'KeefeLeslie J Saucedo
May 10, 2006·Mechanisms of Development·Cristina Molnar, Jose F de Celis
Apr 5, 2005·Mechanisms of Development·Lidia PérezStephen M Cohen
Dec 11, 2007·Mechanisms of Development·Jun WuMarek Mlodzik
Oct 24, 2006·Current Biology : CB·Joseph Parker
Feb 13, 2007·Mechanisms of Development·Tinri Aegerter-WilmsenKonrad Basler
Jun 18, 2009·Developmental Cell·Rachel K Smith-BoltonIswar K Hariharan
Aug 16, 2011·Developmental Cell·Jean-Paul VincentEugenia Piddini
Aug 13, 2008·Developmental Cell·Dragana RoguljaKenneth D Irvine
Sep 15, 2009·Mechanisms of Development·Ulrike NienhausChristof M Aegerter
Jul 25, 2009·Developmental Biology·Thomas J Widmann, Christian Dahmann
Mar 31, 2015·PloS One·Mina EdayoshiHaruhiko Fujiwara
Aug 27, 2014·PloS One·Alexandre DjianeSarah J Bray
Aug 11, 2017·Physiological Reviews·Chris Siebel, Urban Lendahl
Dec 6, 2017·Scientific Reports·Patrizia RomaniValeria Cavaliere
Apr 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marco MilánStephen M Cohen
Jun 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shilin SongHéctor Herranz
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yaron SuissaOffer Gerlitz
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Joseph Parker, Gary Struhl
Feb 22, 2020·Developmental Cell·Lara Barrio, Marco Milán

Related Concepts

Wg protein, Drosophila
Notch protein, Drosophila
Metazoa
Cell Division Phases
Cell Survival
Drosophila melanogaster
Embryonic Structures, Nonmammalian
Flow Cytometry
Cell Surface Proteins
Mosaicism

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