Wingless-type inducible signaling pathway protein-1 (WISP1) adipokine and glucose homeostasis

Journal of Cellular Physiology
Habib YaribeygiAmirhossein Sahebkar

Abstract

Whilst the growing global prevalence of diabetes mellitus is a major healthcare problem, the exact pathophysiology of insulin resistance leading to diabetes mellitus remains unclear. Studies have confirmed that increased adiposity is linked to lower insulin sensitivity through the expression and release of adipocyte-derived proteins such as adipokines. Wingless-type (Wnt) inducible signaling pathway protein-1 (WISP1) is a newly identified adipokine that has important roles in many molecular pathways and cellular events, with the suggestion that WISP1 adipokine is closely correlated to the progression of insulin resistance. Studies have shown that circulatory levels of WISP adipokine are higher in obese patients accompanied with increased insulin resistance. However, the exact role of WISP1 adipokine in the induction of insulin resistance is not completely understood. In this review, we detail the latest evidence showing that the WIPS1 adipokine impairs glucose homeostasis and induces diabetes mellitus.

References

Mar 25, 2008·Cytokine & Growth Factor Reviews·Xu Shi-WenDavid Abraham
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Feb 16, 2011·Journal of Cellular Physiology·Venkatapuram Seenu ReddyBysani Chandrasekar
Dec 2, 2011·Nature Reviews. Drug Discovery·Joon-Il Jun, Lester F Lau
Feb 9, 2013·Advances in Experimental Medicine and Biology·Jorge de Faria Maraschin
Mar 8, 2013·Diabetes Care·UNKNOWN American Diabetes Association
May 3, 2013·Globalization and Health·Julio Lopez-BastidaWillemien Schurer
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Apr 11, 2014·Adipocyte·Alexander J KnightsKim S Bell-Anderson
Oct 5, 2014·Diabetes·Veronica MurahovschiNatalia Rudovich
May 30, 2015·Trends in Pharmacological Sciences·Mathias Fasshauer, Matthias Blüher
Oct 23, 2015·Journal of Molecular Endocrinology·Maria CerneaKaiping Yang
Jun 9, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gulcin Sahin ErsoyOzge Cevik
May 13, 2017·Scientific Reports·Nathalie FerrandMichèle Sabbah
Jul 25, 2017·Osteoarthritis and Cartilage·M H van den BoschM F Young
Nov 13, 2017·Journal of Cell Communication and Signaling·Christopher TackeNatalia Rudovich
Dec 2, 2017·Journal of Gastroenterology and Hepatology·Amanda J CoxNicholas P West
Dec 22, 2017·Journal of the Endocrine Society·Ilaria BarchettaMaria Gisella Cavallo
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Habib YaribeygiAmirhossein Sahebkar
Jan 24, 2018·Stem Cells International·Jia Tang, Takashi Saito
Sep 27, 2018·Metabolism: Clinical and Experimental·Habib YaribeygiAmirhossein Sahebkar
Oct 15, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar

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Citations

Dec 12, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Dec 10, 2020·Journal of Diabetes Research·Habib YaribeygiAmirhossein Sahebkar

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