Winner of the Young Investigator Award of the Society for Biomaterials (USA) for 2016, 10th World Biomaterials Congress, May 17-22, 2016, Montreal QC, Canada: Aligned microribbon-like hydrogels for guiding three-dimensional smooth muscle tissue regeneration

Journal of Biomedical Materials Research. Part a
Soah LeeFan Yang

Abstract

Smooth muscle tissue is characterized by aligned structures, which is critical for its contractile functions. Smooth muscle injury is common and can be caused by various diseases and degenerative processes, and there remains a strong need to develop effective therapies for smooth muscle tissue regeneration with restored structures. To guide cell alignment, previously cells were cultured on 2D nano/microgrooved substrates, but such method is limited to fabricating 2D aligned cell sheets only. Alternatively, aligned electrospun nanofiber has been employed as 3D scaffold for cell alignment, but cells can only be seeded post fabrication, and nanoporosity of electrospun fiber meshes often leads to poor cell distribution. To overcome these limitations, we report aligned gelatin-based microribbons (µRBs) as macroporous hydrogels for guiding smooth muscle alignment in 3D. We developed aligned µRB-like hydrogels using wet spinning, which allows easy fabrication of tissue-scale (cm) macroporous matrices with alignment cues and supports direct cell encapsulation. The macroporosity within µRB-based hydrogels facilitated cell proliferation, new matrix deposition, and nutrient diffusion. In aligned µRB scaffold, smooth muscle cells showed hi...Continue Reading

References

Mar 29, 2002·Journal of Biomedical Materials Research·Todd C McDevittPatrick S Stayton
Dec 18, 2002·Journal of Biomechanics·James H-C WangSavio L-Y Woo
Jan 18, 2003·The International Journal of Biochemistry & Cell Biology·Yassine Amrani, Reynold A Panettieri
Aug 21, 2003·The American Journal of Medicine·Khalil N Bitar
Mar 17, 2004·Biomaterials·Michael E ManwaringPatrick A Tresco
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Jul 23, 2004·Physiological Reviews·Karl-Erik Andersson, Anders Arner
May 1, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marc SutterWim Jiskoot
Jul 26, 2008·World Journal of Urology·Dave ShuklaDarren R Tyson
Feb 27, 2009·Biomedical Microdevices·C M HwangS H Lee
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Deok-Ho KimAndre Levchenko
Apr 24, 2010·Korean journal of urology·Jae Hyun Bae, James J Yoo
Mar 13, 2012·Cardiovascular Research·Delphine Gomez, Gary K Owens
Jan 24, 2014·Advanced Healthcare Materials·Nafiseh MasoumiAli Khademhosseini
Jun 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qihui ZhouYanzhong Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.