Wireless amplified NMR detector for improved visibility of image contrast in heterogeneous lesions

NMR in Biomedicine
Xianchun ZengChunqi Qian

Abstract

To demonstrate the capability of a wireless amplified NMR detector (WAND) to improve the visibility of lesion heterogeneity without the use of exogenous contrast agents, a cylindrically symmetric WAND was constructed to sensitively detect and simultaneously amplify MR signals emitted from adjacent tissues. Based on a two-leg high-pass birdcage coil design, this WAND could be activated by a pumping field aligned along the main field (B0 ), without perturbing MR signal reception. Compared with an equivalent pair of external detectors, the WAND could achieve more than 10-fold gain for immediately adjacent regions. Even for regions with 3.4 radius distance separation from the detector's cylindrical center, the WAND was at least 1.4 times more sensitive than an equivalent pair of surface arrays or at least twice as sensitive as a single-sided external surface detector. When the WAND was inserted into a rat's rectum to observe adjacent tumors implanted beneath the mucosa, it could enhance the detection sensitivity of lesion regions, and thus enlarge the observable signal difference between heterogeneous tissues and clearly identify lesion boundaries as continuous lines in the intensity gradient profile. Hyperintense regions observabl...Continue Reading

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Citations

Oct 3, 2018·The British Journal of Radiology·James P B O'ConnorJohn C Waterton

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