Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation.

Nature Biomedical Engineering
Raza QaziJae-Woong Jeong

Abstract

Both in vivo neuropharmacology and optogenetic stimulation can be used to decode neural circuitry, and can provide therapeutic strategies for brain disorders. However, current neuronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited in their ability to provide simultaneous and prolonged delivery of multiple drugs, are often bulky and lack multifunctionality, and employ custom control systems with insufficiently versatile selectivity for output mode, animal selection and target brain circuits. Here, we describe smartphone-controlled, minimally invasive, soft optofluidic probes with replaceable plug-like drug cartridges for chronic in vivo pharmacology and optogenetics with selective manipulation of brain circuits. We demonstrate the use of the probes for the control of the locomotor activity of mice for over four weeks via programmable wireless drug delivery and photostimulation. Owing to their ability to deliver both drugs and photopharmacology into the brain repeatedly over long time periods, the probes may contribute to uncovering the basis of neuropsychiatric diseases.

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Citations

Jul 17, 2020·Chemical Society Reviews·Yin FangBozhi Tian
Sep 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Nathan P CoussensKurt Rasmussen
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Xiaoran LiRong Wang
Jun 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Changhoon SungSeongjun Park
Aug 7, 2019·Nature Biomedical Engineering·John F Zimmerman, Bozhi Tian
Oct 21, 2020·Scientific Reports·Ilenia MeloniCaroline Murawski
Dec 15, 2020·Biomaterials·Yihang ChenGuosong Hong
Nov 18, 2020·Nature Neuroscience·Abraham Vázquez-GuardadoJohn A Rogers
Aug 4, 2021·Advanced Materials·Xu ChengYihui Zhang
Aug 11, 2021·Neuropharmacology·Adam Gordon-Fennell, Garret D Stuber

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Methods Mentioned

BETA
dissection
chip

Software Mentioned

COMSOL Multiphysics
Prism
COMSOL
Ethovision
GraphPad
SimbleeCOM
Metabond

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