Wireless sensor enables longitudinal monitoring of regenerative niche mechanics during rehabilitation that enhance bone repair.

Bone
Brett S. KlosterhoffR E Guldberg

Abstract

Mechanical loads exerted on the skeleton during activities such as walking are important regulators of bone repair, but dynamic biomechanical signals are difficult to measure inside the body. The inability to measure the mechanical environment in injured tissues is a significant barrier to developing integrative regenerative and rehabilitative strategies that can accelerate recovery from fracture, segmental bone loss, and spinal fusion. Here we engineered an implantable strain sensor platform and longitudinally measured strain across a bone defect in real-time throughout rehabilitation. The results showed that load-sharing permitted by a load-sharing fixator initially delivered a two-fold increase in deformation magnitude, subsequently increased mineralized bridging by nearly three-fold, and increased bone formation by over 60%. These data implicate a critical role for early mechanical cues on the long term healing response as strain cycle magnitude at 1 week (before appreciable healing occurred) had a significant positive correlation with the long-term bone regeneration outcomes. Furthermore, we found that sensor readings correlated with the status of healing, suggesting a role for strain sensing as an X-ray-free healing asses...Continue Reading

References

Jan 26, 1999·Clinical Orthopaedics and Related Research·L E ClaesP Augat
Aug 19, 2004·JAMA : the Journal of the American Medical Association·Ellen F BinderKenneth B Schechtman
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Olli LeppänenTeppo L N Järvinen
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jan 5, 2010·Nature Reviews. Rheumatology·Engin OzciviciClinton T Rubin
Jun 23, 2010·Journal of Biomechanics·Tim WehnerUlrich Simon
Apr 22, 2011·Biomaterials·Joel D BoerckelRobert E Guldberg
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joel D BoerckelRobert E Guldberg
Dec 16, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joel D BoerckelRobert E Guldberg
Apr 10, 2012·Journal of Biomechanical Engineering·Steve A MaasJeffrey A Weiss
Aug 7, 2012·Tissue Engineering. Part a·Carolin SchwarzGeorg N Duda
Sep 12, 2013·Tissue Engineering. Part a·Yash M KolambkarRobert E Guldberg
Aug 6, 2014·Nature Biotechnology·Steven W LaneFiona M Watt
Mar 31, 2015·Biomechanics and Modeling in Mechanobiology·Gregory J MillerElise F Morgan
Sep 8, 2016·JAMA Surgery·Robert ZuraR Grant Steen
Dec 18, 2016·Journal of Biomechanical Engineering·Brett S KlosterhoffRobert E Guldberg
May 2, 2017·Nature Biomedical Engineering·Phillip NadeauGiovanni Traverso
Oct 5, 2017·Journal of Biomechanical Engineering·Brett S KlosterhoffNick J Willett
Nov 9, 2017·Nature Reviews. Molecular Cell Biology·Kyle H Vining, David J Mooney
Feb 8, 2018·Journal of the Mechanical Behavior of Biomedical Materials·R Dana CarpenterDavid L Safranski
Mar 3, 2018·Cell Stem Cell·Thomas A Rando, Fabrisia Ambrosio
Apr 2, 2019·Nature Biomedical Engineering·Clementine M BoutryZhenan Bao

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Citations

Aug 23, 2020·Sensors·Bradley D NelsonKeat Ghee Ong
Jul 7, 2020·Frontiers in Bioengineering and Biotechnology·Hao ChenJincheng Wang
Oct 13, 2020·Npj Regenerative Medicine·Victor CheuyMarzia Bedoni
Feb 14, 2021·Npj Regenerative Medicine·Victor CheuyMarzia Bedoni
Apr 7, 2021·Connective Tissue Research·Brett S KlosterhoffNick J Willett

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