Wireless transcutaneous electrical nerve stimulation device for chemotherapy-induced peripheral neuropathy: an open-label feasibility study

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
J S GewandterNimish A Mohile

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) occurs in approximately 68% of patients who receive neurotoxic chemotherapy and lasts at least 6 months post-chemotherapy in approximately 30% of individuals. CIPN is associated with decreased quality of life and functional impairments. Evidence suggests that CIPN symptoms are caused, in part, by enhanced excitability and impaired inhibition in the central nervous system. Transcutaneous electrical nerve stimulation (TENS) decreases pain by counteracting both of these mechanisms and is efficacious in other conditions associated with neuropathic pain. This single-arm study (n = 29) assessed the feasibility of investigating TENS for CIPN after chemotherapy completion using a wireless, home-based TENS device. Eighty-one percent of eligible patients who were approached enrolled, and 85% of participants who received the TENS device completed the primary (6-week) study term. Qualitative interview data suggest that use of the device on the continuous setting that automatically alternates between 1-h stimulation and rest periods for 5 h/day would be acceptable to most participants. Significant (i.e., p < 0.05) improvements were observed with the EORTC-CIPN20 (percent change from baseline...Continue Reading

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Citations

Jul 15, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziDawn L Hershman
Mar 24, 2020·F1000Research·Richard Gordon-Williams, Paul Farquhar-Smith
Nov 30, 2020·Journal of Pain and Symptom Management·Daniel S ChildsCharles L Loprinzi

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