PMID: 2121570Nov 1, 1990Paper

Wisconsin Epidemiologic Study of Diabetic Retinopathy. XII. Relationship of C-peptide and diabetic retinopathy

Diabetes
R KleinD L DeMets

Abstract

The relationship between plasma C-peptide and the frequency and severity of diabetic retinopathy was examined in a population-based study in Wisconsin in 1984-1986. Individuals with younger- (n = 835) and older- (n = 940) onset diabetes were included. C-peptide was measured by radioimmunoassay with Heding's M1230 antiserum. Retinopathy was determined from stereoscopic fundus photographs. The highest frequencies and most severe retinopathy were found in insulin-using individuals with undetectable or low plasma C-peptide (less than 0.3 nM), whereas the lowest frequencies of retinopathy were found in older-onset overweight individuals not using insulin. In older-onset individuals using insulin, having no detectable C-peptide was significantly associated with the presence of proliferative retinopathy. Otherwise, within each group (younger onset using insulin, older onset using insulin, and older onset not using insulin), after controlling for other characteristics associated with retinopathy, there was no relationship between higher levels of C-peptide and lower frequency of or less severe retinopathy.

Citations

Jan 1, 1995·Documenta Ophthalmologica. Advances in Ophthalmology·T J RimmerP G McNally
Jul 1, 1996·Journal of Diabetes and Its Complications·H T NguyenD R Owens
Nov 12, 2010·BMC Medical Genetics·Suganthalakshmi BalasubbuJ Fielding Hejtmancik
Jul 1, 2006·Biomedical Engineering Online·A Boutayeb, A Chetouani
Oct 27, 2010·PloS One·Bela Anand-ApteJudah Folkman
Apr 29, 2008·Arquivos brasileiros de endocrinologia e metabologia·Melanie RodackiJosé Egídio Paulo de Oliveira
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·C E KullbergUNKNOWN VISS Study Group
Sep 13, 2013·Diabetes Care·Tamara J LecaireRonald Klein
Aug 10, 2010·Arquivos brasileiros de endocrinologia e metabologia·Fabiano Marcel SerfatyJosé Egídio Paulo de Oliveira
Feb 23, 2013·PPAR Research·Andreea CiudinRafael Simó
Feb 26, 2016·Journal of Molecular and Cellular Cardiology·Carlos Zgheib, Kenneth W Liechty

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