PMID: 6975749Sep 1, 1981Paper

Wiskott-Aldrich syndrome: histopathologic findings in the lymph nodes and spleens of 15 patients

Human Pathology
D C SnoverJ H Kersey

Abstract

Seventeen lymph nodes and 13 spleens from 15 patients with the Wiskott-Aldrich syndrome were examined histologically. The material included both biopsy and autopsy specimens. Consistent findings included depletion of small lymphocytes from T cell areas (all cases), prominence of the reticulum cell stroma (all cases), the presence of atypical plasma cells with and without plasmacytosis (16 lymph nodes and 11 spleens), and extramedullary hematopoiesis (13 lymph nodes and 9 spleens). Less frequent features noted were tissue eosinophilia, hemophagocytosis, focal fibrosis, and progressive depletion of germinal centers. One case with a unique abundance of transformed lymphocytes is described.

Citations

Mar 15, 2002·Current Allergy and Asthma Reports·S Nonoyama, H D Ochs
Oct 16, 2008·Immunologic Research·Ted S Strom
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Filip K Swirski
Jun 1, 1992·Acta Paediatrica·W Chlebcewicz-SzubaA Krygier-Stojałowska
Aug 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dennis P O'MalleyAttilio Orazi
Jan 28, 2009·Nature Reviews. Immunology·Jordan S Orange
Mar 1, 1985·International Journal of Dermatology·A D Ormerod
Jun 10, 1998·Springer Seminars in Immunopathology·F FacchettiW Vermi
May 26, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Behdad Navabi, Julia Elizabeth Mainwaring Upton
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Virna Cortez-RetamozoMikael J Pittet
Jan 1, 1985·Cancer Investigation·J D CotelingamE S Jaffe
Jul 1, 1985·Human Pathology·S A YousemC B Carrington

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.