WISP1 Predicts Clinical Prognosis and Is Associated With Tumor Purity, Immunocyte Infiltration, and Macrophage M2 Polarization in Pan-Cancer

Frontiers in Genetics
Xia LiaoYi Lv

Abstract

Cancer is becoming the leading cause of death and a major public health problem. Although many advanced treatment strategies are currently in use, the general prognosis of cancer patients remains dismal due to the high frequency of recurrence, metastasis. The identification of effective biomarkers is important for predicting survival of cancer patients and improving treatment efficacy. In this study, we comprehensively analyzed WNT1-inducible-signaling pathway protein 1 (WISP1) expression and explored its correlation with prognosis in pan-cancer using tumor IMmune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis 2 (GEPIA2). We also examined correlations between WISP1 and immunocyte infiltration using TIMER. We identified genes co-expressed with WISP1 using the LinkedOmics database and analyzed associated gene ontology using Metascape. Finally, we constructed protein-protein interaction networks and examined correlations between genes co-expressed with WISP1 and immunocyte infiltration in pan-cancer. WISP1 level differed between human pan-cancer tissues and normal tissues, indicating its potential as a prognostic biomarker. WISP1 expression was correlated with tumor purity and immunocyte infiltratio...Continue Reading

References

Jan 17, 2003·The Journal of Biological Chemistry·Lilian L SoonKam-Meng Tchou-Wong
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Ralf Weiskirchen
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Feb 4, 2014·Genome Biology·Charity W LawGordon K Smyth
Jan 2, 2015·Journal of Cancer·Paul ZarogoulidisKonstantinos Zarogoulidis
Mar 22, 2015·The International Journal of Biochemistry & Cell Biology·Irem Gurbuz, Ruth Chiquet-Ehrismann
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Oct 27, 2015·International Journal of Molecular Medicine·Jun LiWen G Jiang
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Jun 1, 2016·Journal of Cell Communication and Signaling·Philip A KlenoticZhiyong Lin
Aug 16, 2016·Journal of Cell Communication and Signaling·Herman Yeger, Bernard Perbal
Apr 14, 2017·Cell Death & Disease·Hsiao-Chi TsaiChih-Hsin Tang
Nov 15, 2017·Nucleic Acids Research·Suhas V VasaikarBing Zhang
Apr 6, 2018·Oncology Reports·Wei LiuHuaqin He
Apr 5, 2019·Nature Communications·Yingyao ZhouSumit K Chanda

❮ Previous
Next ❯

Citations

Oct 2, 2020·Current Opinion in Obstetrics & Gynecology·Ilaha IsaliSherif El-Nashar
Apr 4, 2021·International Journal of Molecular Sciences·Yu-Chih ChenKo-Tung Chang
Sep 14, 2021·Frontiers in Genetics·Songling HanJingkui Tian

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq

Software Mentioned

GraphPad
Cytoscape
TIMER
Perl
MCODE
Tumor IMmune Estimation Resource ( TIMER
GraphPad Prism
merge
ImageGP
GEPIA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.