Wistar rats with high versus low rearing activity differ in radial maze performance

Neurobiology of Learning and Memory
Jutta Görisch, R K Schwarting

Abstract

Substantial work has shown that rats although identical in stock, sex, age, and housing conditions can differ considerably in terms of behavior and physiology. Such individual differences, which can be detected by specific behavioral screening tests, are rather stable, that is, they probably reflect a behavioral disposition or trait. Here, we asked whether and how such differences might affect performance in a task of spatial learning and memory, the radial maze. As in our previous work, we used the degree of rearing activity in a novel open field to assign male adult outbred Wistar rats into those with high versus low rearing activity (HRA/LRA rats). They were then tested in a plus-maze for possible differences in anxiety-related behavior. Finally, and most importantly, they were food deprived and underwent maze training using an 8-arm radial maze with four non-baited and four baited arms. One of these arms consistently contained a larger bait size than the other three. In the open field, HRA rats not only showed more rearing behavior, but also more locomotor activity than LRA rats. In the plus-maze, HRA rats again showed more locomotion, but did not differ in open arm time or percentage of open arm entries, that is, conventio...Continue Reading

Citations

Dec 27, 2007·PloS One·Markus Wöhr, Rainer K W Schwarting
Jul 6, 2015·Behavioural Brain Research·Adriano Edgar ReimerMarcus Lira Brandão
Feb 13, 2014·Physiology & Behavior·Andrey Sequeira-CorderoJaime Fornaguera-Trías
Jan 7, 2015·Frontiers in Neuroscience·Andrzej Z Pietrzykowski, Sabine Spijker
Dec 2, 2014·Neurobiology of Learning and Memory·Andrea Mora-GallegosJuan C Brenes
Aug 3, 2016·Disease Models & Mechanisms·Judith R HombergBart A Ellenbroek
May 23, 2020·The International Journal of Neuroscience·Osman SinenAysel Agar
Oct 16, 2018·Pharmacological Reports : PR·Carlos Eduardo de Souza MenezesDanielle Macêdo

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