Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct-acting antivirals for hepatitis C virus

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yutaka YasuiNamiki Izumi

Abstract

The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon-free, direct-acting antivirals (DAAs). This is a retrospective cohort study that included 567 patients who underwent antiviral therapy with an interferon-free DAA regimen and achieved SVR. Serum WFA+ -M2BP was measured after SVR. Factors predictive of HCC occurrence and recurrence were analyzed in the patients after stratification by previous treatment history of HCC. Among 518 patients who had no history of HCC, 13 developed HCC. Post-SVR WFA+ -M2BP ≥1.75 cut-off index (C.O.I., P < 0.001) and α-fetoprotein (AFP) level ≥6 ng/mL (P = 0.01) were significant predictors of HCC development. Multivariate analysis showed that post-SVR WFA+ -M2BP ≥1.75 C.O.I. was an independent factor significantly associated with the development of HCC (hazard ratio [HR] 6.0; 95% confidence interval (CI), 1.8-19.4; P = 0.003). Among 49 patients who had a previous history of HCC, 22 had recurrence after SVR. Post-SVR AFP ≥6 ng/mL was the only factor associated with recurrenc...Continue Reading

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Citations

Jan 10, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Emi Inoue-ShinomiyaMamoru Watanabe
Aug 3, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobuhiko OgasawaraHiromitsu Kumada
Dec 1, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobuhiko OgasawaraHiromitsu Kumada
Nov 22, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiji MiyoshiTadashi Suzuki
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Jun 17, 2020·Clinical and Molecular Hepatology·Takako Inoue, Yasuhito Tanaka
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Jun 20, 2020·World Journal of Gastroenterology : WJG·Shereen A SalehGhada A Mohamed
Feb 6, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nobuharu TamakiNamiki Izumi
Mar 12, 2021·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masanori AtsukawaKatsuhiko Iwakiri

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