PMID: 8609455Feb 1, 1996Paper

Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera

International Journal of Radiation Biology
P U DeviT Sugahara

Abstract

Withaferin A, a steroidal lactone isolated from the roots of the Indian medicinal plant Withania somnifera, reduced survival of V79 cells in a dose-dependent manner. LD50 for survival was 16 microM. One-hour treatment with a non-toxic dose of 2.1 microM before irradiation significantly enhanced cell killing, giving a sensitizer enhancement ratio (SER) of 1.5 for 37% survival and 1.4 for 10% survival. SER increased with drug dose, but at higher doses the increased lethality appears to be due to two effects-- drug toxicity and radiosensitization. The drug induced a G2/M block, with a maximum accumulation of cells in G2-M phase at 4 h after treatment with 10.5 microM withaferin A in 1 h. The applicability of this drug as a radiosensitizer in cancer therapy needs to be explored.

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Citations

Sep 8, 2009·Natural Product Research·M K KaulG N Qazi
Feb 19, 2004·Cancer Biotherapy & Radiopharmaceuticals·Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Ravikumar AalinkeelStanley A Schwartz
Jan 7, 2005·Biological & Pharmaceutical Bulletin·Ganesh Chandra Jagetia, Venkatasubbaiah Ashoka Kumar Venkatesha
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Apr 4, 2014·Reviews on Environmental Health·Seyed Jalal Hosseinimehr
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Jan 2, 2019·JAD Reports·Steffi WitterAgo Samoson
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Apr 19, 2011·Integrative Cancer Therapies·Kiran B AithalSatish Bola Sadashiva Rao
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Dec 12, 2012·Inflammopharmacology·Shailendra Kapoor

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