Withaferin A: a potential therapeutic agent against COVID-19 infection.

Journal of Ovarian Research
Alex R Straughn, Sham S Kakar

Abstract

The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide. In addition, the pandemic has claimed the lives of over 530,000 people worldwide. Age and the presence of underlying comorbid conditions have been found to be key determinants of patient mortality. One such comorbidity is the presence of an oncological malignancy, with cancer patients exhibiting an approximate two-fold increase in mortality rate. Due to a lack of data, no consensus has been reached about the best practices for the diagnosis and treatment of cancer patients. Interestingly, two independent research groups have discovered that Withaferin A (WFA), a steroidal lactone with anti-inflammatory and anti-tumorigenic properties, may bind to the viral spike (S-) protein of SARS-CoV-2. Further, preliminary data from our research group has demonstrated that WFA does not alter expression of ACE2 in the lungs of tumor-bearing female mice. Downregulation of ACE2 has recently been demonstrated to increase the severity of COVID-19. Therefore, WFA demonstrates real potential as a therapeutic agent to treat or prevent the spread of COVID-19 ...Continue Reading

References

Apr 28, 2007·The Journal of Pathology·I HammingH van Goor
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·Tadashi YoshidaPatrice Delafontaine
Nov 27, 2019·Journal of Ovarian Research·Alex R Straughn, Sham S Kakar
Feb 19, 2020·The Lancet Oncology·Wenhua LiangJianxing He
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 28, 2020·Circulation·Kaiming WangGavin Y Oudit
Apr 1, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L ZhangM Zhou
Apr 29, 2020·Journal of Gynecologic Oncology·Yusuke KobayashiJae Weon Kim
May 10, 2020·Current Oncology Reports·Rohit GosainMarc S Ernstoff
May 12, 2020·Frontiers in Oncology·Oronzo BrunettiNicola Silvestris
May 20, 2020·Frontiers in Oncology·Lucia FratinoGiordano Beretta

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Citations

Feb 9, 2021·Journal of Photochemistry and Photobiology. B, Biology·Sachin Ashok ThoratAnnamalai Muthusamy
Dec 4, 2020·Future Drug Discovery·Vivek K KashyapMeena Jaggi
Feb 26, 2021·Scientific Reports·Sinead M O'DonovanRobert E McCullumsmith
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arumugam Vijaya AnandKuldeep Dhama
Dec 22, 2020·Journal of Proteome Research·Yi Zhang, Liang V Tang
Sep 8, 2021·Environmental Science and Pollution Research International·Rajeshwari SinghDevesh Tewari

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