Withania somnifera ameliorates lead-induced augmentation of adrenergic response in rat portal vein

Indian Journal of Pharmacology
Subrata Kumar HoreSatish Kumar Garg

Abstract

Present study was undertaken to elucidate the ameliorating potential of Withania somnifera root extract (WRE) against lead-induced augmentation of adrenergic response in rat portal vein. In-vitro studies were conducted on effect of lead alone and lead+WRE on rat-isolated portal vein while in-vivo studies were done in three groups of 12 rats each; Group-II and III received 0.5% lead acetate and 1.0% WRE + 0.5% lead acetate, respectively, in drinking water for 12 weeks whereas group-I served as control. Adrenaline and noradrenaline levels in brain and blood were determined by HPLC assay while vascular reactivity of portal vein to lead and WRE was determined by measuring the isometric tension. Following in-vitro exposure, lead did not alter the contractile effect of phenylephrine. In-vivo studies revealed that contractile effect of lead on portal vein was significantly potentiated and it was antagonized by prazosin (10(-7) M) and WRE (1%). WRE treatment significantly reduced elevated blood noradrenaline (37.80%) and restored noradrenaline level in brain (39.39%) in lead-exposed animals. These values were almost comparable to the control group. But it failed to significantly affect the blood and brain adrenaline levels. Results sug...Continue Reading

References

Aug 1, 1990·Journal of Applied Toxicology : JAT·A VyskocilI Tenjnorová
Jan 1, 1980·Journal of Cardiovascular Pharmacology·R C WebbD F Bohr
Apr 15, 2000·Toxicology and Applied Pharmacology·D A TsaoH R Chang
Apr 20, 2000·Toxicology·T L GallantI Chu
May 19, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S S ChaurasiaA Kar
Jul 14, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·M J RonisC K Lumpkin
Mar 8, 2002·Pharmacology & Toxicology·I ValenciaC Castillo
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Denis NashEllen K Silbergeld
Aug 4, 2004·Environmental Health Perspectives·Shirng-Wern TsaihHoward Hu
Dec 8, 2004·American Journal of Epidemiology·Marc G WeisskopfHoward Hu

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Citations

Feb 7, 2016·Neuroscience Letters·Mohammad AshafaqSuhel Parvez

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Graph Pad Prism
Chromatopak

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