Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation

Neuromolecular Medicine
Muskan Gupta, Gurcharan Kaur

Abstract

Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammation but due to their adverse effects, their usage is not well accepted. Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. In Ayurveda, Ashwagandha (Withania somnifera) is well known for its immunomodulatory properties. The current study is an extension of our previous report on in vitro model system and was aimed to investigate anti-neuroinflammatory potential of water extract from the Ashwagandha leaves (ASH-WEX) against systemic LPS-induced neuroinflammation and associated behavioral impairments using in vivo rat model system. Oral feeding of ASH-WEX for 8 weeks significantly ameliorated the anxiety-like behavior as evident from Elevated plus maze test. Suppression of reactive gliosis, inflammatory cytokines production like TNF-α, IL-1β, IL-6, and expres...Continue Reading

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Citations

Aug 17, 2019·BMC Complementary and Alternative Medicine·Muskan Gupta, Gurcharan Kaur
Nov 23, 2020·Environmental Science and Pollution Research International·Ajay KumarSatwinderjeet Kaur
May 21, 2021·Frontiers in Pharmacology·Akash SaggamBhushan Patwardhan
Jul 11, 2021·Neurochemistry International·Ashish KumarRenu Wadhwa
Apr 19, 2019·Journal of Natural Products·Vijay P SonarGiuseppe Talani
Jan 7, 2022·Naunyn-Schmiedeberg's Archives of Pharmacology·Sukhdev SinghArti Singh

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Methods Mentioned

BETA
PCR
transfection
ubiquitination
nuclear translocation

Software Mentioned

AlphaEase FC
Graphpad prism
NIS elements AR
Sigma Stat

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