Withdrawal from chronic amphetamine produces persistent anxiety-like behavior but temporally-limited reductions in monoamines and neurogenesis in the adult rat dentate gyrus.

Neuropharmacology
Jeffrey L BarrGina L Forster

Abstract

Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. Chronic amphetamine increases anxiety states in rats when measured at 24 h and at 2 weeks of withdrawal. However, the effects of chronic amphetamine exposure and withdrawal on long term anxiety-like behavior and adult neurogenesis in the dentate gyrus are unknown. Adult male rats were administered amphetamine (2.5 mg/kg, ip.) daily for two weeks. Anxiety-like behaviors were increased markedly in amphetamine-treated rats following four weeks of withdrawal from amphetamine. Plasma corticosterone level was unaltered by amphetamine treatment or withdrawal. However, norepinephrine and serotonin concentrations were selectively reduced in the dentate gyrus 20 h following amphetamine treatment. This effect did not persist through the four week withdrawal period. In separate experiments, rats received bromodeoxyuridine to label cells in S-phase, prior to or immediately following amphetamine treatment. Newly generated cells were quantified to measure extent of progenitor cell proliferation and neurogenesis following treatment or withdrawal. Progenitor cell pr...Continue Reading

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Citations

Aug 13, 2011·Psychopharmacology·Patrick E RothwellJonathan C Gewirtz
Feb 3, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Daniel Toledano, Pascale Gisquet-Verrier
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Nov 23, 2017·Frontiers in Neuroscience·Nathan VinzantGina L Forster
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May 6, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Vinícia Garzella MetzCamila Simonetti Pase

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