Withdrawal of immunosuppresive agents in the treatment of disseminated coccidioidomycosis

The American Journal of Medicine
J E KaplanA L Kisch

Abstract

Disseminated coccidioidomycosis is a systemic fungal infection that causes high mortality in the renal transplatn patient. Cell-mediated immunity, which appears to be the relevant host defense mechanism, is impaired by the immunosupressive agents used to prevent allograft rejection. In the case presented, immunosuppressive therapy was stopped as an adjunct to treatment of this infection. The patient has shown evidence of improvement, and his allograft has continued to function nine months after the withdrawal of immunosuppressive therapy and 18 months after the diagnosis. In vitro lymphocyte function studies indicate that the impairment in cell-mediated immunity detected prior to withdrawal of immunosuppressive therapy has persisted, probably accounting for allograft survival. Withdrawal of immunosuppressive therapy may prolong survival in renal transplant patients with disseminated coccidioidomycosis. Additionally, depression in cell-mediated immunity associated with the fungal infection itself may be sufficient to prevent allograft rejection in these patients.

References

Jun 1, 1977·Transplantation·G P SchröterR Well
Feb 1, 1975·Cellular Immunology·A CatanzaroK M Moser
Feb 18, 1956·Journal of the American Medical Association·C E SMITHS A SIMONS

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Citations

Oct 6, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E Blair, J L Logan
Jul 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John N GalgianiNicholas Theodore
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Janis E Blair
Jan 1, 1997·Clinical Microbiology Reviews·R Patel, C V Paya

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