Withdrawal symptoms and rebound syndromes associated with switching and discontinuing atypical antipsychotics: theoretical background and practical recommendations

CNS Drugs
Anja CeroveckiMichael Riedel

Abstract

With the widespread use of atypical or second-generation antipsychotics, switching treatment has become current practice and more complicated, as the pharmacological profiles of these agents differ substantially despite their similarity in being 'atypical'. All share the ability to block dopamine D₂ receptors, and most of them also block serotonin 5-HT2A receptors. Apart from these common features, some atypical antipsychotics are also able to block or stimulate other dopamine or serotonin receptors, as well as histaminergic, muscarinergic or adrenergic receptors. As a result of the varying receptor affinities, in switching or discontinuing compounds several possible pitfalls have to be considered, including the occurrence of withdrawal and rebound syndromes. This article reviews the pharmacological background of functional blockade or stimulation of receptors of interest in regard to atypical antipsychotics and the implicated potential withdrawal and rebound phenomena. A MEDLINE search was carried out to identify information on withdrawal or rebound syndromes occurring after discontinuation of atypical antipsychotics. Using the resulting literature, we first discuss the theoretical background to the functional consequences of ...Continue Reading

References

Sep 23, 2014·Expert Review of Neurotherapeutics·Vladan Starcevic
Nov 18, 2014·Expert Opinion on Drug Safety·Richard MusilMichael Hamerle
Jun 5, 2015·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Richard BalonKarl Rickels
Jul 19, 2014·Psychiatry Research·Deena AshoorianRhonda Clifford
Jun 26, 2017·Psychotherapy and Psychosomatics·Guy ChouinardMasaomi Iyo
Nov 24, 2017·Clinical Psychology & Psychotherapy·Elena TombaGiovanni A Fava
Nov 2, 2017·Archives of Women's Mental Health·Marley Doyle, Mila Grossman
Nov 9, 2018·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Lily Xu, Saroja Krishnaswamy
Jun 11, 2019·Clinical Pediatrics·Rachel Ballard, Nia Heard-Garris
Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Young Sup WooWon-Myong Bahk
Jan 19, 2020·Expert Opinion on Drug Safety·Barbara B BartonRichard Musil
Jan 4, 2017·Schizophrenia Bulletin·Hiroyoshi TakeuchiGary Remington
Apr 25, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Tamara PringsheimThomas R E Barnes
May 2, 2018·International Journal of Bipolar Disorders·Maximilian PilhatschMichael Bauer
Jun 14, 2019·Journal of Applied Research in Intellectual Disabilities : JARID·Rohit ShankarRegi Alexander
Dec 21, 2019·JAMA : the Journal of the American Medical Association·Alastair J FlintPatricia Marino
Feb 23, 2018·Clinical Medicine Insights. Case Reports·A Suárez-LledóR Jódar
Feb 20, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Amanda C CapinoPeter N Johnson
Jul 17, 2020·Therapeutic Advances in Psychopharmacology·Joanna MoncrieffMark Abie Horowitz
Dec 10, 2016·Psychopharmacology·Yury S TarahovskyNadezhda M Zakharova
Nov 3, 2020·Frontiers in Psychiatry·Lasse BrandtStefan Gutwinski

Citations

Nov 1, 1978·The American Journal of Psychiatry·G ChouinardL Annable
Dec 15, 1978·Psychopharmacology·P Muller, P Seeman
Aug 15, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T H Svensson, U Strömbom
Jan 1, 1976·Journal of Neural Transmission·A O Donoso, A M Bannza
Jan 1, 1991·Progress in Brain Research·D J WoodwardJ E Cheun
Jan 1, 1991·Physiological Reviews·J C SchwartzM Ruat
Sep 1, 1991·Brain Research Bulletin·H WadaA Yamatodani
Mar 1, 1991·Schizophrenia Research·D P van Kammen, M Kelley
Jun 18, 1990·Behavioural Brain Research·V Devauges, S J Sara
Jan 1, 1990·Pharmacology & Therapeutics·E E HaaksmaH Timmerman
Jun 1, 1990·Trends in Pharmacological Sciences·P H AndersenM G Caron
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
May 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Jan 1, 1985·Psychopharmacology·A PerényiG Bagdy
Apr 1, 1973·British Journal of Pharmacology·K P BhargavaY P Srivastava
Jan 1, 1980·The American Journal of Psychiatry·G Chouinard, B D Jones
Jan 1, 1982·British Journal of Pharmacology·B N DhawanR C Srimal
Dec 1, 1995·Archives of General Psychiatry·R J BaldessariniD L Garver
Jun 1, 1995·Journal of Clinical Psychopharmacology·J M RadfordR L Borison
Jul 1, 1995·Brain Research. Cognitive Brain Research·S J SaraA Hervé
Apr 1, 1995·British Journal of Pharmacology·J M ArrangJ C Schwartz
Jan 1, 1995·Life Sciences·C J SchmidtM G Palfreyman
Jun 1, 1994·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·B L Roth
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·G P Reynolds
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H Meador-WoodruffS J Watson
Apr 1, 1994·British Journal of Pharmacology·P Malmberg-AielloA Bartolini
Nov 19, 1993·Brain Research·K OokumaK Fujimoto
Jan 1, 1993·Journal of Neural Transmission. General Section·E SchlickerM Göthert
Apr 1, 1993·Journal of Clinical Psychopharmacology·M A ParsaH Y Meltzer
Jul 1, 1995·British Journal of Pharmacology·I MarshallC R Chapple
Sep 1, 1995·British Journal of Pharmacology·K FurukawaR Chess-Williams
Apr 1, 1996·The American Journal of Psychiatry·S Kapur, Gary Remington
Oct 1, 1995·Pharmacopsychiatry·H G Baumgarten, Z Grozdanovic
Jan 17, 1996·Annals of the New York Academy of Sciences·A FisherA D Korczyn

Related Concepts

Nystagmus
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Serotonin Measurement
HTR2A wt Allele
Serotonin
Withdrawal Symptoms
Psychoses, Drug
HTR2A gene
Adverse Event

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