PMID: 8949735Sep 21, 1996Paper

Withdrawal syndrome in 2 drug addicts after intravenous injection of buprenorphine?

La Presse médicale
L GourarierH Durand

Abstract

Adequate dosage of sublingual buprenorphine is now recommended for substitution treatment of severe opioid dependance. We report two cases of acute discomfort, probably linked to withdrawal syndrome, after an IV injection of high doses of buprenorphine in opiate dependant patients. Data on the pharmacokinetics and neurobiochemical aspects of buprenorphine are compared with those of other opiates. A major issue of this work is a guideline for inducing substitution treatment with this "unique" partial agonist/antagonist of endorphinic receptors.

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