WITHDRAWN. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV

The Cochrane Database of Systematic Reviews
Innocent Omeje, Charles I Okwundu

Abstract

The current recommended antiretroviral treatment is a highly active antiretroviral therapy (HAART). Although HAART has been associated with improved clinical response to treatment, issues of adherence and viral resistance are major challenges limiting its success. There is a need for an effective and safe first-line regimen, to cope with the ever-increasing incidence of non-adherence and primary resistance. A more recent first-line treatment regimen consists of Tenofovir (TDF, 300 mg) + Emtricitabine (FTC, 200 mg) + Efavirenz (EFV, 600 mg). To evaluate the effects and safety of TDF + FTC + EFV as first-line treatment for patients with HIV. We searched the Cochrane Central Register of Controlled Trials, EMBASE, GATEWAY, LILACS, PubMed, AEGIS, and the WHO prospective clinical trials registry in November 2011. Randomized controlled trials evaluating the effects of TDF + FTC + EFV compared with other HAART regimens. Two reviewers independently assessed trial eligibility and risk of bias, and extracted data from the included study. Only one study involving 517 antiretroviral-naive HIV infected adults was included in this review. Participants were randomly assigned to receive either a regimen of TDF (300 mg), FTC (200mg), and EFV (60...Continue Reading

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