Withering away--25,000 years of genetic decline preceded cave bear extinction

Molecular Biology and Evolution
Mathias StillerMichael Knapp


The causes of the late Pleistocene megafaunal extinctions are still enigmatic. Although the fossil record can provide approximations for when a species went extinct, the timing of its disappearance alone cannot resolve the causes and mode of the decline preceding its extinction. However, ancient DNA analyses can reveal population size changes over time and narrow down potential causes of extinction. Here, we present an ancient DNA study comparing late Pleistocene population dynamics of two closely related species, cave and brown bears. We found that the decline of cave bears started approximately 25,000 years before their extinction, whereas brown bear population size remained constant. We conclude that neither the effects of climate change nor human hunting alone can be responsible for the decline of the cave bear and suggest that a complex of factors including human competition for cave sites lead to the cave bear's extinction.


Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erik Trinkaus
Oct 5, 2010·Molecular Biology and Evolution·Beth ShapiroAndrew Rambaut
Aug 2, 2011·Genome Research·Ludovic OrlandoEske Willerslev
May 12, 2012·BMC Genomics·Mikkel SchubertLudovic Orlando
Feb 13, 2016·Biology Letters·Dan Chang, Beth Shapiro
Sep 24, 2011·International Journal of Evolutionary Biology·Virginie FabreEstelle Herrscher
Apr 13, 2011·Molecular Ecology Resources·Simon Yw Ho, Beth Shapiro
Jun 8, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Leon HuynenDavid M Lambert
Feb 27, 2016·Global Change Biology·Eleftheria PalkopoulouLove Dalén
Feb 18, 2016·Molecular Ecology·Adrien Rieux, François Balloux
Jul 3, 2016·Systematic Biology·Mandev S GillMarc A Suchard
Oct 13, 2016·Die Naturwissenschaften·Mateusz BacaPaweł Mackiewicz
Oct 8, 2016·Molecular Ecology Resources·Adrien Rieux, Camilo E Khatchikian
Nov 4, 2011·Nature·Eline D LorenzenEske Willerslev
Feb 13, 2018·Ecology and Evolution·Felicia VachonTimothy R Frasier
Aug 17, 2019·Scientific Reports·Joscha GretzingerVerena J Schuenemann
Aug 29, 2018·Nature Ecology & Evolution·Axel BarlowMichael Hofreiter
Oct 21, 2010·Mitochondrial DNA·Simon Yw Ho, Robert Lanfear
Aug 21, 2015·PloS One·Antonio González-MartínHéctor Rangel-Villalobos


May 24, 2001·Molecular Biology and Evolution·Marc A SuchardJ S Sinsheimer
Jan 9, 2004·Current Biology : CB·Michael HofreiterSvante Pääbo
Oct 2, 2004·Science·Anthony D BarnoskyAlan B Shabel
Nov 30, 2004·Science·B ShapiroAlan Cooper
Feb 11, 2005·Molecular Biology and Evolution·Alexei J DrummondOliver G Pybus
Mar 30, 2007·BioTechniques·Nadin Rohland, Michael Hofreiter
Apr 5, 2007·Nature Protocols·Holger RömplerMichael Hofreiter

Related Concepts

Competitive Behavior
Extinction, Species
History, Ancient
Grizzly Bears
Ancient DNA
Ursus spelaeus

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