Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Valérie D'AcremontBlaise Genton

Abstract

The availability of a rapid diagnostic test for malaria (RDTm) allows accurate diagnosis at all levels of health facilities. The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result. We conducted a prospective 2-arm longitudinal study in areas of Tanzania that are moderately and highly endemic for malaria. Children with a history of fever were managed routinely by resident clinicians of 2 health facilities, except that no antimalarials were prescribed if the RDTm result was negative. Children were followed up at home on day 7. The main outcome was the occurrence of complications in children with negative RDTm results; children with positive RDTm results were followed up for the same outcomes for indirect comparison. One thousand children (median age, 24 months) were recruited. Six hundred three children (60%) had a negative RDTm result. Five hundred seventy-three (97%) of these children were cured on day 7. Forty-nine (8%) of the children with negative RDTm results spontaneously visited the dispensary before day 7, compared with 10 (3%) of the children with positive RDTm results. All children who had negative initial results had negative resul...Continue Reading

Citations

Apr 30, 2013·The Lancet Infectious Diseases·Cedric P YansouniMarleen Boelaert
Dec 27, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicolas SennBlaise Genton
Feb 6, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·E BottieauJ Jacobs
Dec 20, 2012·BMC Public Health·Colombe Coffie ComoéBenjamin G Koudou
Jul 5, 2013·Malaria Journal·Gro E A StrømBjørn Blomberg
Jun 19, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Zeno BisoffiJef Van den Ende
Dec 7, 2011·The American Journal of Tropical Medicine and Hygiene·Alexandre Macedo de OliveiraSamuel Mabunda
Jun 15, 2013·Malaria Research and Treatment·Andria RuskWendy Prudhomme O'Meara
Jun 6, 2013·Biomarkers in Medicine·Laurens Manning, Timothy Mark Earls Davis
Jun 5, 2014·The New England Journal of Medicine·Valérie D'AcremontBlaise Genton
Jul 31, 2014·Malaria Journal·Tesfay AbrehaHiwot Teka
Aug 12, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joseph KeatingJoshua O Yukich
Sep 19, 2014·Current Infectious Disease Reports·Cedric P YansouniMomar Ndao
Feb 28, 2014·The New England Journal of Medicine·Valérie D'AcremontBlaise Genton
Oct 8, 2013·Critical Care Clinics·Matthew P Cheng, Cedric P Yansouni
Feb 19, 2013·Trends in Parasitology·V Bhargavi RaoAzra C Ghani
Nov 8, 2013·Health Policy and Planning·Gary GaumerAllyala Krishna Nandakumar
Apr 11, 2015·PloS One·Martin Kayitale MbonyeJean Pierre Van Geertruyden
Aug 16, 2016·Malaria Journal·David BellCaitlin C McConnico
Feb 26, 2015·The American Journal of Tropical Medicine and Hygiene·Olufemi AjumobiGabriele Poggensee

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