PMID: 3760397Sep 1, 1986Paper

Within- and between-day reproducibility of isocapnic cold air challenges in subjects with asthma

The Journal of Allergy and Clinical Immunology
P TessierJ L Malo

Abstract

Eight adult subjects with asthma had isocapnic cold air challenges on 4 different days. Three consecutive tests were performed on each visit with functional recovery between tests. Subjects were asked to breathe dry cold air (-20 degrees C) for progressively increasing levels of minute ventilation (7.5, 15, 30, and 60 L/min and maximal voluntary ventilation) until a 20% fall in FEV1 had been reached or when maximal voluntary ventilation was done. FEV1 was assessed between each level. The doses of respiratory heat exchange and minute ventilation causing 10%, 15%, and 20% changes in FEV1 were interpolated from dose-response curves. The within- and between-day 95% confidence intervals based on a single determination on the loge scale varied from +/- 0.32 to 0.59 for the indices derived from respiratory heat exchange. Reproducibility of the between-day results was more satisfactory than for the corresponding within-day assessments. No significant within-day tachyphylaxis was demonstrated for these indices.

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·A CartierJ Y Dubois
Nov 1, 1981·The Journal of Allergy and Clinical Immunology·F E HargreaveJ Dolovich

❮ Previous
Next ❯

Citations

Nov 1, 1988·Medical & Biological Engineering & Computing·R D Farley, K R Patel
Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N CaireJ L Malo
Feb 26, 2016·European Clinical Respiratory Journal·Sandra D Anderson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.