Within-Host and Between-Host Evolution in SARS-CoV-2-New Variant's Source.

Viruses
Karin Moelling

Abstract

Some of the newly emerging corona viral variants show high numbers of mutations. This is unexpected for a virus with a low mutation rate due to an inherent proof-reading system. Could such a variant arise under very special conditions occurring in a host where the virus replicates and mutates in a rather unlimited fashion, such as in immune compromised patients? The virus was shown to replicate in an immunosuppressed cancer patient for more than 105 days and might be a source of new variants. These patients are asymptomatic and the virus may therefore escape detection and attention and be high-risk. Similarly, HIV-infected individuals may be immunocompromised and support coronavirus replication with increased mutation rates. The patients may promote "within-host evolution". Some of the viruses present in such a highly mutagenic swarm or quasispecies within one patient may become founders and cause a pandemic by further "between-host evolution". B.1.1.7 with 23 mutations may be such a case. Immunosuppressed patients can be identified and treated by the synthetic antibody cocktails as passive immunization and kept under control. Immunosuppressed patients can be easily identified and supervised by healthcare workers-once they beco...Continue Reading

References

Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Nov 10, 2015·Nature Medicine·Vineet D MenacheryRalph S Baric
Mar 15, 2018·Trends in Microbiology·Katherine S XueJesse D Bloom
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Apr 21, 2020·Journal of Medical Virology·Adam Brufsky
May 31, 2020·The American Journal of Pathology·Eric SalazarJames M Musser
Jul 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Estefanía MiraManuel Santamaria
Sep 2, 2020·BioRxiv : the Preprint Server for Biology·Bryan A JohnsonVineet D Menachery
Sep 10, 2020·Nature·Ewen Callaway
Nov 8, 2020·Science·Kevin W NgGeorge Kassiotis
Nov 12, 2020·The New England Journal of Medicine·Bina ChoiJonathan Z Li
Nov 27, 2020·Nature Communications·Lucy van DorpFrançois Balloux
Dec 19, 2020·Molecular Cell·Fran RobsonWai-Lung Ng
Jan 31, 2021·Lancet·Ester C SabinoNuno R Faria
Apr 29, 2021·BioRxiv : the Preprint Server for Biology·Anthony P WestPamela J Bjorkman

❮ Previous
Next ❯

Citations

May 11, 2021·Environmental Research·Uttpal AnandMarco Race

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.